☆ 4.8 Article

Assembling synergistic peptide-drug conjugates for dual-targeted treatment of cancer metastasis

NANO TODAY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Multifunctional Supramolecular Filament Hydrogel Boosts Anti-Inflammatory Efficacy In Vitro and In Vivo

Jie Deng et al.

Summary: This study combines an antioxidant, a non-steroidal anti-inflammatory drug, and a self-assembled peptide to form a hydrogel that reduces the production of inflammatory mediators. It demonstrates superior therapeutic efficacy in an animal model compared to clinically used drugs.

ADVANCED FUNCTIONAL MATERIALS (2022)

添加到收藏夹

Review Materials Science, Multidisciplinary

Carrier-free nanomedicines for cancer treatment

Li-Han Liu et al.

Summary: The past decade has seen significant advances in the development of carrier-free nanomedicines, which are attractive due to their high biosafety, drug loading capacities, simple compositions, and simplified synthesis procedures. Extensive efforts have been made to expand the scope of carrier-free nanomedicines and improve their therapeutic performance through the exploration of new excipients, therapeutic agents, self-assembly methods, and mechanisms. This review summarizes the research progress and practical applications of carrier-free nanomedicines in cancer therapy.

PROGRESS IN MATERIALS SCIENCE (2022)

添加到收藏夹

Article Chemistry, Medicinal

Shuttling of Peptide-Drug Conjugates by G Protein-Coupled Receptors Is Significantly Improved by Pulsed Application

Isabelle Ziffert et al.

Summary: Research shows that in the drug shuttle system of G protein-coupled receptors, a higher amount of peptide uptake can be achieved by pulsing the application of the drug, and the efficiency of recycling receptors and peptide uptake varies in different cell systems.

CHEMMEDCHEM (2021)

添加到收藏夹

Article Engineering, Biomedical

Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency

Man-Di Wang et al.

Summary: PDC drugs offer advantages of improved drug targetability and reduced adverse effects compared to traditional chemotherapy, but their poor permeability to tumor cells needs to be addressed. The designed PDC drug molecule forms nanoclusters upon binding cellular receptor, enhancing treatment efficacy. This strategy leverages assembly principles to promote peptide penetration into cells and increase intracellular drug bioavailability.

BIOMATERIALS (2021)

添加到收藏夹

Article Chemistry, Medicinal

Peptide-Drug Conjugates with Different Linkers for Cancer Therapy

Mona Alas et al.

Summary: Drug conjugates are compounds consisting of chemotherapeutic or cytotoxic agents linked to targeting ligands via a covalent linker, used for cancer treatment. The linker in drug conjugates plays a crucial role in the circulation time and release of the drug at the target site.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Improved Antiglioblastoma Activity and BBB Permeability by Conjugation of Paclitaxel to a Cell-Penetrative MMP-2-Cleavable Peptide

Dan Hua et al.

Summary: A novel dual-functional nanocomplex drug delivery system, SynB3-PVGLIG-PTX, was developed based on the strategy of peptide-drug conjugates. It exhibited specific inhibition on proliferation, migration, and invasion of GBM cells in vitro through the cleavage of MMP-2 to release PTX.

ADVANCED SCIENCE (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Trends in peptide drug discovery

Markus Muttenthaler et al.

Summary: This Perspective summarizes key trends in peptide drug discovery and development, including human hormones, elegant medicinal chemistry and rational design strategies, peptide drugs derived from nature, and major breakthroughs in molecular biology and peptide chemistry. It also emphasizes lessons from earlier approaches that are still relevant today and discusses emerging strategies impact on peptide drug discovery.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enzymatic Assemblies of Thiophosphopeptides Instantly Target Golgi Apparatus and Selectively Kill Cancer Cells**

Weiyi Tan et al.

Summary: Introducing a sulfur atom into phosphopeptides enables rapid targeting of Golgi apparatus and selective killing of cancer cells. The resulting thiophosphopeptide self-assembles after alkaline phosphatase-catalyzed dephosphorylation, enters cells, and accumulates in Golgi apparatus, inhibiting cancer cells effectively.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages

Wenqi Yu et al.

Summary: Breast cancer is the most common tumor in women and its metastasis increases malignancy and mortality. Nanomedicines have shown great potential in treating cancer metastasis by specifically designed functions at different stages of the process, providing new solutions.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Structure-Based Programming of Supramolecular Assemblies in Living Cells for Selective Cancer Cell Inhibition

Liangbo Hu et al.

Summary: By designing, synthesizing, and assembling an enzymatic programmable peptide system, we induced molecular assemblies formation spatiotemporally in living cancer cells, resulting in mainly necroptosis of glioblastoma cells. The stability and glycosylation of molecules play a crucial role in determining the bioactivity, as evidenced by detailed mechanistic studies showing site-specific formation of assemblies capable of activating the downstream cell death pathway.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Peptide-Based Supramolecular Systems Chemistry

Fahmeed Sheehan et al.

Summary: Peptide-based supramolecular systems chemistry aims to mimic the ability of life forms to achieve a wide range of functions using conserved building blocks and chemical reactions. This field is increasingly focused on system-level design to access complex functions that emerge when multiple reactions and interactions are coordinated and integrated.

CHEMICAL REVIEWS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Noncanonical Amino Acids for Hypoxia-Responsive Peptide Self-Assembly and Fluorescence

Binbin Hu et al.

Summary: The design of endogenous stimuli-responsive amino acids allows for precise modulation of proteins or peptides under a biological microenvironment, as demonstrated in the development of efficient hypoxia imaging probes using a noncanonical amino acid. The unique properties of the synthesized amino acid facilitate the creation of aromatic peptides undergoing NTR-responsive self-assembly, leading to the development of morphology-transformable supramolecular probes for imaging hypoxic tumor cells. This versatile amino acid provides a powerful toolkit for synthetic biology and the creation of novel biomaterials responsive to biological environments.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Antagonists Promote Mitochondrial Dysfunction

Mingming Li et al.

Summary: Mitochondrion-targeting therapy has great potential in cancer treatment, but limited therapeutic efficiency is a challenge. A mitochondrion-targeting supramolecular antagonist was developed, inducing tumor cell death by promoting apoptosis and preventing survival simultaneously. The combined therapeutic effect of the BH3 domain and CPT drug in the supramolecular antagonist efficiently inhibits tumor growth.

NANO LETTERS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs)

Bethany M. Cooper et al.

Summary: Peptides offer versatility in oncology drug discovery, with peptide-drug conjugates showing promise in targeting tumors. Despite limitations such as slow progress and limited oral bioavailability, new approaches have enhanced peptide stability, leading to two molecules on the market and various variations in clinical trials.

CHEMICAL SOCIETY REVIEWS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Design of Unsymmetric Reverse Bolaamphiphiles for Cell-Sensitive Hydrogel Degradation and Drug Release

Rami W. Chakroun et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers

Hao Su et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Tubustecan Hydrogel as Chemotherapeutic Carrier to Improve Tumor Penetration and Local Treatment Efficacy

Feihu Wang et al.

ACS NANO (2020)

添加到收藏夹

Article Engineering, Biomedical

Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel

Feihu Wang et al.

NATURE BIOMEDICAL ENGINEERING (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Enzymatic Noncovalent Synthesis

Hongjian He et al.

CHEMICAL REVIEWS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Controlled Supramolecular Assembly Inside Living Cells by Sequential Multistaged Chemical Reactions

Michaela Pieszka et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Biomimetic peptide self-assembly for functional materials

Aviad Levin et al.

NATURE REVIEWS CHEMISTRY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

TAT-RasGAP317-326 kills cells by targeting inner-leaflet-enriched phospholipids

Marc Serulla et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Review Oncology

Cancer progression and the invisible phase of metastatic colonization

Christoph A. Klein

NATURE REVIEWS CANCER (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Elastase-triggered H2S delivery from polymer hydrogels

Mingjun Zhou et al.

CHEMICAL COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Peptide-Drug Conjugate-Based Nanocombination Actualizes Breast Cancer Treatment by Maytansinoid and Photothermia with the Assistance of Fluorescent and Photoacoustic Images

Yanan Sun et al.

NANO LETTERS (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Hierarchically oriented organization in supramolecular peptide crystals

Chengqian Yuan et al.

NATURE REVIEWS CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Proline Isomerization-Regulated Tumor Microenvironment-Adaptable Self-Assembly of Peptides for Enhanced Therapeutic Efficacy

Mingming Li et al.

NANO LETTERS (2019)

添加到收藏夹

Review Cell Biology

Actin-microtubule crosstalk in cell biology

Marileen Dogterom et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

添加到收藏夹

Article Chemistry, Medicinal

The Current State of Peptide Drug Discovery: Back to the Future?

Antoine Henninot et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy

Guo-Bin Qi et al.

ADVANCED MATERIALS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with NF-kappa B Targeting for Selective Necroptosis of Cancer Cells

Jie Zhou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Peptide-Based Multifunctional Nanomaterials for Tumor Imaging and Therapy

Chi Zhang et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-Assembled Nanostructures Regulate H2S Release from Constitutionally Isomeric Peptides

Yin Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Molecular engineering solutions for therapeutic peptide delivery

Handan Acar et al.

CHEMICAL SOCIETY REVIEWS (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Self-assembling prodrugs

Andrew G. Cheetham et al.

CHEMICAL SOCIETY REVIEWS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Assembly of Peptide Amphiphiles

Mark P. Hendricks et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Emerging Biological Principles of Metastasis

Arthur W. Lambert et al.

CELL (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Peptide-drug conjugates as effective prodrug strategies for targeted delivery

Yin Wang et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of cell migration and invasion mediated by the TAT-RasGAP317-326 peptide requires the DLC1 tumor suppressor

D. Barras et al.

ONCOGENE (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment

Zhou J. Deng et al.

ACS NANO (2013)

添加到收藏夹

Review Chemistry, Multidisciplinary

Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications

Min Hee Lee et al.

CHEMICAL REVIEWS (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Nanostructures Formed by Anticancer Drug Assembly

Andrew G. Cheetham et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

添加到收藏夹

Review Pharmacology & Pharmacy

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

Jun Fang et al.

ADVANCED DRUG DELIVERY REVIEWS (2011)

添加到收藏夹

Review Multidisciplinary Sciences

A Perspective on Cancer Cell Metastasis

Christine L. Chaffer et al.

SCIENCE (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

High resolution crystal structures of the p120 RasGAP SH3 domain

Birthe Ross et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

添加到收藏夹

Article Chemistry, Organic

The use of Nile Red to monitor the aggregation behavior in ternary surfactant-water-organic solvent systems

MCA Stuart et al.

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells

D Michod et al.

ONCOGENE (2004)

添加到收藏夹

Review Physiology

Phosphoinositide regulation of the actin cytoskeleton

HL Yin et al.

ANNUAL REVIEW OF PHYSIOLOGY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.