4.4 Article

Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus

期刊

MUSCLE & NERVE
卷 66, 期 6, 页码 723-729

出版社

WILEY
DOI: 10.1002/mus.27719

关键词

diabetic peripheral neuropathy; low T3 syndrome; nerve conduction study; severity; type 2 diabetes mellitus

资金

  1. National Natural Science Foundation of China [81901273]
  2. Natural Science Foundation of Zhejiang Province [LQ21H090018, LY19H090014]

向作者/读者索取更多资源

This study investigated the association between low T3 syndrome and DPN in patients with T2DM, and found that low T3 syndrome was independently associated with the occurrence and severity of DPN.
Introduction/Aims Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus. Diabetic patients often have thyroid dysfunction. The aim of this study was to investigate the association between low triiodothyronine (T3) syndrome and DPN in patients with type 2 diabetes mellitus (T2DM). Methods A retrospective review was performed of 928 patients with T2DM for whom data was available for clinical manifestations and nerve conduction studies (NCS), and of 134 non-diabetic controls. The composite Z scores of conduction velocity and amplitude were calculated. Low T3 syndrome was defined as T3 levels below the lower limit of the reference interval. Results Among the patients with T2DM, 632 (68.1%) had DPN, and a larger proportion of these patients presented with low T3 syndrome than patients without DPN. After adjusting for potential confounders, low T3 syndrome was independently associated with the occurrence of DPN (odds ratio [OR] = 2.049, 95% confidence interval [CI] 1.319-3.181, p = .001) and the severity of DPN (OR = 1.597, 95% CI 1.030-2.476, p = .036). Adding the criterion of low T3 syndrome improved the prognostic performance of the traditional model (age + gender + diabetic duration + glycated hemoglobin [HbA1c]) for predicting DPN. Discussion Low T3 syndrome is associated with a higher risk and increased severity of DPN in patients with T2DM. These findings suggest that low T3 syndrome could be a predictor for risk stratification in patients with T2DM.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据