Suitability of Automated Writing Measures for Clinical Trial Outcome in Writer's Cramp

Background: Writer's cramp (WC) dystonia is a rare disease that causes abnormal postures during the writing task. Successful research studies for WC and other forms of dystonia are contingent on identifying sensitive and specific measures that relate to the clinical syndrome and achieve a realistic sample size to power research studies for a rare disease. Although prior studies have used writing kinematics, their diagnostic performance remains unclear. Objective: This study aimed to evaluate the diagnostic performance of automated measures that distinguish subjects with WC from healthy volunteers. Methods: A total of 21 subjects with WC and 22 healthy volunteers performed a sentence-copying assessment on a digital tablet using kinematic and hand recognition softwares. The sensitivity and specificity of automated measures were calculated using a logistic regression model. Power analysis was performed for two clinical research designs using these measures. The test and retest reliability of select automated measures was compared across repeat sentence-copying assessments. Lastly, a correlational analysis with subject- and clinician-rated outcomes was performed to understand the clinical meaning of automated measures. Results: Of the 23 measures analyzed, the measures of word legibility and peak accelerations distinguished subjects with WC from healthy volunteers with high sensitivity and specificity and demonstrated smaller sample sizes suitable for rare disease studies, and the kinematic measures showed high reliability across repeat visits, while both word legibility and peak accelerations measures showed significant correlations with the subjectand clinician-rated outcomes. Conclusions: Novel automated measures that capture key aspects of the disease and are suitable for use in clinical research studies of WC dystonia were identified. (c) 2022 International Parkinson and Movement Disorder Society.

Automated summary

This study evaluated the diagnostic performance of automated measures in distinguishing subjects with writer's cramp from healthy volunteers. The results showed that measures of word legibility and peak accelerations had high sensitivity and specificity, and were suitable for rare disease studies. Additionally, kinematic measures showed high reliability across repeat visits, and both word legibility and peak accelerations measures were significantly correlated with clinical outcomes.