期刊
MOLECULES
卷 27, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/molecules27175498
关键词
Chrysanthemum boreale Makino; oxidative stress; hydrogen peroxide; cell death; cell survival; neurodegenerative diseases
资金
- Junior Faculty Support Program of Pusan National University [2019R1C1C1007045]
- National Research Foundation of Korea
This study found that Chrysanthemum boreale Makino extract (CBME) effectively suppresses oxidative stress-induced neurotoxicity in SH-SY5Y cells through multiple molecular mechanisms, providing evidence for its neuroprotective properties.
Oxidative stress has been demonstrated to play a pivotal role in the pathological processes of many neurodegenerative diseases. In the present study, we demonstrated that Chrysanthemum boreale Makino extract (CBME) suppresses oxidative stress-induced neurotoxicity in human neuroblastoma SH-SY5Y cells and elucidated the underlying molecular mechanism. Our observations revealed that CBME effectively protected neuronal cells against H2O2-induced cell death by preventing caspase-3 activation, Bax upregulation, Bcl-2 downregulation, activation of three mitogen-activated protein kinases (MAPKs), cAMP response element-binding protein (CREB) and NF-kappa B phosphorylation, and iNOS induction. These results provide evidence that CBME has remarkable neuroprotective properties in SH-SY5Y cells against oxidative damage, suggesting that the complementary or even alternative role of CBME in preventing and treating neurodegenerative diseases is worth further studies.
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