Anti-Inflammatory, Antioxidative, and Nitric Oxide-Scavenging Activities of a Quercetin Nanosuspension with Polyethylene Glycol in LPS-Induced RAW 264.7 Macrophages

Review Biochemistry & Molecular Biology

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

Maleki Parisa Dana et al.

Summary: Polyphenols, natural compounds with beneficial properties, can increase the sensitivity of cancer cells to chemotherapeutic agents and affect other mechanisms for overcoming chemoresistance in cancer cells.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Review Chemistry, Medicinal

O-Glycoside quercetin derivatives: Biological activities, mechanisms of action, and structure-activity relationship for drug design, a review

Seyedeh Roya Alizadeh et al.

Summary: Quercetin, a valuable natural flavonoid, exhibits various biological activities, but its low solubility and poor bioavailability limit its applications. Researchers have designed and synthesized new quercetin derivatives to improve its biological activities. This review focused on categorizing and studying the biological activities, structure-activity relationship, and action mechanism of O-glycoside quercetin derivatives.

PHYTOTHERAPY RESEARCH (2022)

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Review Chemistry, Medicinal

Quercetin and its derivates as antiviral potentials: A comprehensive review

Amalia Di Petrillo et al.

Summary: Quercetin, a flavonoid found in fruits and vegetables, shows potential as an antiviral agent by inhibiting virus infection, interacting with viral replication enzymes, and reducing inflammation. It can be used in combination with other drugs to enhance effects and reduce side effects. The review aims to summarize the antiviral activities of quercetin on various human viral infections.

PHYTOTHERAPY RESEARCH (2022)

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Article Biochemistry & Molecular Biology

The Protective Effect of a Unique Mix of Polyphenols and Micronutrients against Neurodegeneration Induced by an In Vitro Model of Parkinson's Disease

Francesca Pacifici et al.

Summary: The combination of polyphenols and micronutrients, known as A5(+), has shown synergistic and innovative efficacy against cellular pathological processes in Parkinson's disease. It reduces inflammation, activates extracellular signal-regulated kinases, increases cell viability, and promotes cellular differentiation into dopaminergic neurons.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Anti-Inflammatory Effects of Mitrephora sirikitiae Leaf Extract and Isolated Lignans in RAW 264.7 Cells

Supachoke Mangmool et al.

Summary: The study showed that Mitrephora sirikitiae leaves and some isolated lignans exhibit potent anti-inflammatory activity through the inhibition of secretion and synthesis of PGE(2), NO, and TNF-α in RAW 264.7 mouse macrophage cells.

MOLECULES (2022)

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Review Nutrition & Dietetics

Modulation of Inflammation by Plant-Derived Nutraceuticals in Tendinitis

Anna-Lena Mueller et al.

Summary: Tendinitis is a common tendon disease caused by mechanical overuse, injuries, drug abuse, and lifestyle factors. Nuclear factor kappa B is an important pro-inflammatory transcription factor that regulates genes involved in inflammation, degradation, and cell death. Plant-derived nutraceuticals can target multiple signaling pathways and suppress inflammation in tendinitis.

NUTRIENTS (2022)

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Article Medicine, General & Internal

Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review

Silvia Massa et al.

Summary: Human papillomavirus (HPV) remains a significant health threat globally, and natural substances, particularly phytochemicals, are being investigated as potential sources for antiviral and anticancer drugs. Some natural bioactives and dietary phytochemicals have shown promise in interfering with HPV and improving the efficacy of chemotherapy. Although there have been clinical trials, further assessment and research are needed to explore the clinical application of these natural substances.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Nutrition & Dietetics

Dietary Therapy in Prevention of Cardiovascular Disease (CVD)-Tradition or Modernity? A Review of the Latest Approaches to Nutrition in CVD

Elzbieta Szczepanska et al.

Summary: Improper dietary behavior can influence the development of cardiovascular diseases, but certain food components can have cardioprotective effects. Polyphenols, most abundant in multicolored vegetables and fruits, have been shown to lower blood pressure, improve lipid profile, and regenerate vascular endothelium. Therefore, maintaining a varied diet can help prevent cardiovascular diseases.

NUTRIENTS (2022)

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Article Biochemical Research Methods

Exploration of natural compounds with anti-SARS-CoV-2 activity via inhibition of SARS-CoV-2 Mpro

Shiv Bharadwaj et al.

Summary: By utilizing in silico and in vitro methods, natural compounds have been identified as promising candidates for inhibiting SARS-CoV-2 M-pro. These compounds show significant binding energy and molecular interactions with essential residues in the active site of the virus's main protease.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Biotechnology & Applied Microbiology

Antioxidant and Antibacterial Profiling of Pomegranate-pericarp Extract Functionalized-zinc Oxide Nanocomposite

Mahendra Singh et al.

Summary: This study successfully synthesized zinc oxide nanocomposites functionalized with pomegranate pericarp ethanolic extract, which exhibited significant radical scavenging and antibacterial activity, as well as high cell viability for human cells.

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING (2021)

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Article Immunology

Anti-inflammatory potential of Quercetin in COVID-19 treatment

Ali Saeedi-Boroujeni et al.

Summary: SARS-CoV-2, causing severe inflammatory pneumonia, is considered to have excessive inflammation as a risk factor, with cytokine storm playing a critical role in patient deaths. Quercetin may suppress inflammation by inhibiting the NLRP3 inflammasome, potentially serving as a treatment for severe inflammation and COVID-19 patients.

JOURNAL OF INFLAMMATION-LONDON (2021)

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Article Multidisciplinary Sciences

Determination of tyrosinase-cyanidin-3-O-glucoside and (-/ plus )-catechin binding modes reveal mechanistic differences in tyrosinase inhibition

Kyung Eun Lee et al.

Summary: The study investigated the inhibitory mechanisms of cyanidin-3-O-glucoside and (-/+)-catechin on tyrosinase using computational simulations and in vitro assessments. Molecular docking and dynamics simulations indicated a stable binding of the flavonoids with tyrosinase, with (-/+)-catechin showing substantial inhibition. The findings suggest further research on (-/+)-catechin as a potential drug candidate for tyrosinase-related diseases.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro

Minsu Jang et al.

Summary: EGCG, a green tea polyphenol, has been shown to inhibit coronavirus replication and reduce cytotoxicity, leading to decreased levels of coronavirus RNA and protein in infected cells.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Neurosciences

Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract

Hoda E. Mohamed et al.

NUTRITIONAL NEUROSCIENCE (2020)

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Article Chemistry, Multidisciplinary

Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health

Bahare Salehi et al.

ACS OMEGA (2020)

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Article Cardiac & Cardiovascular Systems

Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor Cu-64-Macrin in Mice, Rabbits, and Pigs

Matthias Nahrendorf et al.

CIRCULATION-CARDIOVASCULAR IMAGING (2020)

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Review Cell Biology

Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine

Dengyu Yang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Pharmacology & Pharmacy

Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin

Ludovico Esposito et al.

PHARMACEUTICS (2020)

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Review Immunology

Polyphenols in the treatment of autoimmune diseases

Haroon Khan et al.

AUTOIMMUNITY REVIEWS (2019)

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Article Biochemistry & Molecular Biology

Application of pH-Responsive Fucoidan/Chitosan Nanoparticles to Improve Oral Quercetin Delivery

Ana Isabel Barbosa et al.

MOLECULES (2019)

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Review Chemistry, Medicinal

Antibacterial activity of flavonoids and their structure-activity relationship: An update review

Faegheh Farhadi et al.

PHYTOTHERAPY RESEARCH (2019)

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Review Integrative & Complementary Medicine

Effects of coffee consumption on glucose metabolism: A systematic review of clinical trials

Caio E. G. Reis et al.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2019)

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Article Food Science & Technology

Preparation and structural properties of amylose complexes with quercetin and their preliminary evaluation in delivery application

Rui Lv et al.

INTERNATIONAL JOURNAL OF FOOD PROPERTIES (2019)

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Article Materials Science, Multidisciplinary

Antioxidant electrospun zein nanofibrous web encapsulating quercetin/cyclodextrin inclusion complex

Zeynep Aytac et al.

JOURNAL OF MATERIALS SCIENCE (2018)

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Article Food Science & Technology

Antioxidant and anti-inflammatory activities of quercetin and its derivatives

Marija Lesjak et al.

JOURNAL OF FUNCTIONAL FOODS (2018)

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Review Chemistry, Medicinal

Anticancer potential of quercetin: A comprehensive review

Abdur Rauf et al.

PHYTOTHERAPY RESEARCH (2018)

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Article Chemistry, Medicinal

Nanosuspension of quercetin: preparation, characterization and effects against Aedes aegypti larvae

Leticie Zulmira da Silva Pessoa et al.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2018)

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Article Chemistry, Medicinal

Anti-inflammatory activity of Echium amoenum extract on macrophages mediated by inhibition of inflammatory mediators and cytokines expression

Najmeh Naseri et al.

RESEARCH IN PHARMACEUTICAL SCIENCES (2018)

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Review Biochemistry & Molecular Biology

In vivo ROS production and use of oxidative stress-derived biomarkers to detect the onset of diseases such as Alzheimer's disease, Parkinson's disease, and diabetes

Aya Umeno et al.

FREE RADICAL RESEARCH (2017)

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Review Chemistry, Medicinal

Quercetin and derivatives: useful tools in inflammation and pain management

Gabriele Carullo et al.

FUTURE MEDICINAL CHEMISTRY (2017)

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Article Medicine, Research & Experimental

The macrophage and its role in inflammation and tissue repair: mathematical and systems biology approaches

Joanne L. Dunster

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2016)

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Review Biochemistry & Molecular Biology

Cell Proliferation and Cytotoxicity Assays

Aysun Adan et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016)

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Review Biochemistry & Molecular Biology

Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine

Ju-Suk Nam et al.

MOLECULES (2016)

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Review Nutrition & Dietetics

Quercetin, Inflammation and Immunity

Yao Li et al.

NUTRIENTS (2016)

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Article Biochemistry & Molecular Biology

The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies.

Catalina Carrasco-Pozo et al.

REDOX BIOLOGY (2016)

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Review Immunology

Inflammasomes: mechanism of assembly, regulation and signalling

Petr Broz et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Review Oncology

Link between chronic inflammation and human papillomavirus-induced carcinogenesis

Jose Verissimo Fernandes et al.

ONCOLOGY LETTERS (2015)

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Article Nutrition & Dietetics

Estimated Daily Intake and Seasonal Food Sources of Quercetin in Japan

Haruno Nishimuro et al.

NUTRIENTS (2015)

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Article Pharmacology & Pharmacy

Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells

Jianjun Wu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

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Article Agriculture, Multidisciplinary

Quercetin Nanosuspensions Produced by High-Pressure Homogenization

Ayse Karadag et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

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Article Chemistry, Physical

Effect of pH on the chemical modification of quercetin and structurally related flavonoids characterized by optical (UV-visible and Raman) spectroscopy

Z. Jurasekova et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2014)

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Article Chemistry, Applied

Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability

Bin Li et al.

CARBOHYDRATE POLYMERS (2013)

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Review Microbiology

Recent Advances in Understanding Enteric Pathogenic Escherichia coli

Matthew A. Croxen et al.

CLINICAL MICROBIOLOGY REVIEWS (2013)

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Article Infectious Diseases

LysR family activator-regulated major facilitator superfamily transporters are involved in Vibrio cholerae antimicrobial compound resistance and intestinal colonisation

Sushu Chen et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2013)

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Article Pharmacology & Pharmacy

Experimental and mesoscale computational dynamics studies of the relationship between solubility and release of quercetin from PEG solid dispersions

Daniel P. Otto et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Article Toxicology

Anti-inflammatory effect of Mentha longifolia in lipopolysaccharide-stimulated macrophages: Reduction of nitric oxide production through inhibition of inducible nitric oxide synthase

Parastoo Karimian et al.

JOURNAL OF IMMUNOTOXICOLOGY (2013)

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Article Medicine, General & Internal

Effect of Silymarin (Milk Thistle) on Liver Disease in Patients With Chronic Hepatitis C Unsuccessfully Treated With Interferon Therapy A Randomized Controlled Trial

Michael W. Fried et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

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Article Plant Sciences

Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells

Ziqiang Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2012)

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Article Infectious Diseases

Rapid evolution of fluoroquinolone-resistant Escherichia coli in Nigeria is temporally associated with fluoroquinolone use

Adebayo Lamikanra et al.

BMC INFECTIOUS DISEASES (2011)

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Article Biophysics

Dissolution enhancement of quercetin through nanofabrication, complexation, and solid dispersion

M. Kakran et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2011)

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Article Agriculture, Multidisciplinary

Bovine Serum Albumin Nanoparticle Promotes the Stability of Quercetin in Simulated Intestinal Fluid

Ru Fang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

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Article Chemistry, Medicinal

Preparation and Characterization of Quercetin Nanocrystals

N. G. Sahoo et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

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Review Biochemistry & Molecular Biology

Inhibiting NF-kappa B activation by small molecules as a therapeutic strategy

Subash C. Gupta et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2010)

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Review Nutrition & Dietetics

Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management

Ashley J. Vargas et al.

NUTRITION REVIEWS (2010)

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Article Pharmacology & Pharmacy

Enhancement of dissolution rate of gliclazide using solid dispersions with polyethylene glycol 6000

S. Biswal et al.

AAPS PHARMSCITECH (2008)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of oxidative stress-induced carcinogenesis: From epidemiology to oxygenomics

Shinya Toyokuni

IUBMB LIFE (2008)

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Review Microbiology

From soil to gut:: Bacillus cereus and its food poisoning toxins

Lotte P. Stenfors Arnesen et al.

FEMS MICROBIOLOGY REVIEWS (2008)

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Article Agriculture, Multidisciplinary

Oxidative DNA damage preventive activity and antioxidant potential of Stevia rebaudiana (Bertoni) Bertoni, a natural sweetener

Srijani Ghanta et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2007)

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Article Thermodynamics

Solubility of flavonoids in organic solvents

Latifa Chebil et al.

JOURNAL OF CHEMICAL AND ENGINEERING DATA (2007)

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Article Biochemistry & Molecular Biology

Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells

Shamima Islam et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Article Pharmacology & Pharmacy

In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity

Rubia Casagrande et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2007)

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Article Agriculture, Multidisciplinary

Modified 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method to measure antioxidant capacity of selected small fruits and comparison to ferric reducing antioxidant power (FRAP) and 2,2′-diphenyl-1-picrylhydrazyl (DPPH) methods

M Ozgen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2006)

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Article Endocrinology & Metabolism

Coffee, caffeine, and risk of type 2 diabetes - A prospective cohort study in younger and middle-aged US women

RM van Dam et al.

DIABETES CARE (2006)

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Article Materials Science, Multidisciplinary

The rheological properties and characterization of bentonite dispersions in the presence of non-ionic polymer PEG

A Alemdar et al.

JOURNAL OF MATERIALS SCIENCE (2005)

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Article Agriculture, Multidisciplinary

Quercetin-4' glucoside is more potent than quercetin-3-glucoside in protection of rat intestinal mucosa homogenates against iron ion-induced lipid peroxidation

K Murota et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2004)

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Article Pharmacology & Pharmacy

In-vitro anti-inflammatory effect of Eucalyptus globulus and Thymus vulgaris:: nitric oxide inhibition in J774A.1 murine macrophages

E Vigo et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2004)

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Review Gastroenterology & Hepatology

Peroxynitrite and inflammatory bowel disease

DM McCafferty

GUT (2000)

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Anti-Inflammatory, Antioxidative, and Nitric Oxide-Scavenging Activities of a Quercetin Nanosuspension with Polyethylene Glycol in LPS-Induced RAW 264.7 Macrophages

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