Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway

Article Cell Biology

Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway

Ning Wang et al.

Summary: Dex promotes M2 polarization of microglia, attenuates oxidative stress and inflammation, and protects against cerebral ischemic injury by activating the Nrf2/HO-1 pathway and inhibiting NLRP3 inflammasome.

INFLAMMATION RESEARCH (2022)

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Article Plant Sciences

Pteryxin attenuates LPS-induced inflammatory responses and inhibits NLRP3 inflammasome activation in RAW264.7 cells

Dong Zhen et al.

Summary: Pteryxin has anti-inflammatory properties by inhibiting NF-kappa B/MAPK signaling pathway and blocking NLRP3 activation, suggesting it as a potential treatment option for inflammatory-related diseases.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Immunology

Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe

Yuqin Niu et al.

Summary: Tumorigenesis often involves chronic inflammation and the tumor microenvironment (TME) consists of various cells and extracellular components. Tumor cells and other cells undergo genetic and epigenetic alterations in the TME, with macrophages being the most plastic immune cell type and playing a crucial role in these alterations.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Sinomenine increases the methylation level at specific GCG site in mPGES-1 promoter to facilitate its specific inhibitory effect on mPGES-1

Jin-Fang Luo et al.

Summary: The study found that sinomenine (SIN) regulates the expression of mPGES-1 through its DNA methylation induction effect. The demethylating agent 5-azacytidine (5-AzaC) can reverse the inhibitory effect of SIN on mPGES-1. Additionally, SIN selectively increases the methylation level of the promoter region in the mPGES-1 gene, whereas pretreatment with 5-AzaC suppresses this effect. These findings contribute to predicting and diagnosing diseases with high expression of mPGES-1 and provide new ideas and solutions for clinical diagnosis and treatment as well as drug development.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2022)

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Article Pharmacology & Pharmacy

Lactobacillus plantarum RS-09 Induces M1-Type Macrophage Immunity Against Salmonella Typhimurium Challenge via the TLR2/NF-κB Signalling Pathway

Chenpei Zhao et al.

Summary: Probiotic Lactobacillus plantarum RS-09 has been found to modulate M1 macrophage polarization and induce TLR2-linked NF-kappa B signaling activity, enhancing the immune response against Salmonella Typhimurium infection. Additionally, RS-09 relieves splenomegaly, body weight loss, and death rate associated with the infection.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Cell Biology

DNMT3A and DNMT3B in Breast Tumorigenesis and Potential Therapy

Xiaxia Man et al.

Summary: This article reviews the roles of DNMT3A and DNMT3B in breast tumorigenesis and development, discusses their SNP and mutations in breast cancer, and summarizes how they are regulated by non-coding RNAs and signaling pathways. It emphasizes that targeting the expression levels of DNMT3A and DNMT3B may be a promising therapeutic approach for breast cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Chemistry, Medicinal

Lycorine Ameliorates Thioacetamide-Induced Hepatic Fibrosis in Rats: Emphasis on Antioxidant, Anti-Inflammatory, and STAT3 Inhibition Effects

Huda Mohammed Alkreathy et al.

Summary: Lycorine inhibits TAA-induced liver fibrosis in rats partly through its antioxidative and anti-inflammatory effects, as well as the inhibition of STAT3 signaling.

PHARMACEUTICALS (2022)

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Article Biochemistry & Molecular Biology

Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells

Min Yeong Park et al.

Summary: Inflammation is a severe problem in the immune system, and it can release pro-inflammatory mediators. This study investigated the effect of scutellarein on inflammation, using LPS-stimulated cells. The results showed that scutellarein reduced the expression of certain proteins and could be used as a compound to treat inflammation.

MOLECULES (2022)

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Article Biochemistry & Molecular Biology

Anti-Inflammatory Activity of Essential Oil from Zingiber ottensii Valeton in Animal Models

Wisit Thitinarongwate et al.

Summary: The study evaluated the anti-inflammatory activity of Zingiber ottensii (ZO) essential oil and found that it reduces inflammation and edema in animal models. The mechanisms of action may involve the inhibition of TNF-alpha expression and the production of COX-2 and PGE(2).

MOLECULES (2022)

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Review Pharmacology & Pharmacy

Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation

Wenqian Guo et al.

Summary: DNA methylation plays a pleiotropic role in Chinese herbal medicine, influencing plant growth, bioactive compound biosynthesis, pharmaceutical mechanisms, and constitution theory validation, which contributes significantly to the development and research of Chinese herbal medicine.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Anti-Inflammatory Effects of 6-Methylcoumarin in LPS-Stimulated RAW 264.7 Macrophages via Regulation of MAPK and NF-κB Signaling Pathways

Jin-Kyu Kang et al.

Summary: The study demonstrated that 6-MC reduced the levels of nitric oxide and prostaglandin E-2 without causing cytotoxicity, and also decreased the expression of pro-inflammatory cytokines in a concentration-dependent manner in LPS-stimulated cells. Western blot results showed that 6-MC treatment decreased the protein levels of iNOS and COX-2 induced by LPS, while mechanistic studies revealed its inhibitory effects on the MAPK and NF-kappa B pathways.

MOLECULES (2021)

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Article Medicine, Research & Experimental

DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway

Hai-Di Li et al.

CLINICAL SCIENCE (2020)

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Article Oncology

Autocrine IL6-Mediated Activation of the STAT3-DNMT Axis Silences the TNFα-RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells

Alyssa D. Smith et al.

CANCER RESEARCH (2020)

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Review Cell Biology

Macrophage polarization in intestinal inflammation and gut homeostasis

Tamara Cristina Moreira Lopes et al.

INFLAMMATION RESEARCH (2020)

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Article Pharmacology & Pharmacy

Anti-nociceptive and anti-inflammatory potentials of Akebia saponin D

Li-li Gong et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Review Gastroenterology & Hepatology

Role of epigenetics in transformation of inflammation into colorectal cancer

Zhen-Hua Yang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Article Immunology

Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling

Huining Fan et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Oncology

DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

Ssu-Chuan Lai et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Cell & Tissue Engineering

Asperosaponin VI stimulates osteogenic differentiation of rat adipose-derived stem cells

Xingpo Ding et al.

REGENERATIVE THERAPY (2019)

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Article Plant Sciences

Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner

Heikki Erasalo et al.

JOURNAL OF NATURAL PRODUCTS (2018)

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Article Pharmacology & Pharmacy

Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages

Jin-Fang Luo et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Immunology

Cell- and tissue-specific epigenetic changes associated with chronic inflammation in insulin resistance and type 2 diabetes mellitus

Velosha Naidoo et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2018)

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Article Immunology

Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-α, and IL-6 via AP-1, NF-κB, and JAK-STAT inactivation in RAW 264.7 macrophages

Seung-Bin Lee et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2017)

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Article Multidisciplinary Sciences

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Eri H. Kobayashi et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Asperosaponin VI promotes bone marrow stromal cell osteogenic differentiation through the PI3K/AKT signaling pathway in an osteoporosis model

Ke Ke et al.

SCIENTIFIC REPORTS (2016)

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Review Oncology

The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)

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INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Article Endocrinology & Metabolism

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

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MOLECULAR ENDOCRINOLOGY (2014)

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Article Plant Sciences

Plant Extracts of the Family Lauraceae: A Potential Resource for Chemopreventive Agents that Activate the Nuclear Factor- Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway

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PLANTA MEDICA (2014)

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Review Immunology

Molecular mechanisms that influence the macrophage M1-M2 polarization balance

Nan Wang et al.

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Cancer-related inflammation: Common themes and therapeutic opportunities

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DNA Methylation of Colon Mucosa in Ulcerative Colitis Patients: Correlation with Inflammatory Status

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MECHANISMS OF DISEASE The Pathogenesis of Rheumatoid Arthritis

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NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice

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Impact of inflammation on epigenetic DNA methylation -: a novel risk factor for cardiovascular disease?

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1

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Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway

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