Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments

A series of N-acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity. The most pronounced antibacterial activity was shown by the compounds with isoxazole fragments, while the adamantane derivatives showed the greatest antiviral effect. It was found that the majority of anabasine derivatives showed significant analgesic activity, reducing the pain response of animals to the irritating effect of acetic acid. The presence of a high level of antimicrobial and antiviral activity in newly synthesized compounds makes it possible to consider them promising for further study of their pharmacological properties.

Automated summary

A series of N-acyl derivatives of anabasine and cytisine were synthesized to discover new medicinal agents based on natural products. The compounds were tested for antimicrobial, antifungal, antiviral, and analgesic activity, with compounds containing isoxazole fragments showing strong antibacterial activity and adamantane derivatives demonstrating the greatest antiviral effect. Anabasine derivatives exhibited significant analgesic activity. The newly synthesized compounds showed promising levels of antimicrobial and antiviral activity, suggesting potential for further pharmacological studies.