4.6 Article

A Rapid and Sensitive LC-MS/MS Method for the Quantitation of Physalin A with Special Consideration to Chemical Stability in Rat Plasma: Application to a Pharmacokinetic Study

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Article Plant Sciences

Silencing Tautomerization to Isolate Unstable Physalins from Physalis minima

Jiang-Ping Wu et al.

Summary: The tautomerization mechanism of unstable physalins was elucidated, leading to the successful separation of tautomers and isolation of highly pure products. Fifteen new physalins and seventeen known analogues were isolated from Physalis minima L. These compounds exhibited significant antiproliferative and anti-inflammatory activities.

JOURNAL OF NATURAL PRODUCTS (2022)