期刊
MOLECULES
卷 27, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/molecules27186022
关键词
Adefovir; zirconium molybdate; multi-walled carbon nanotubes; electrochemical detection; serum; urine
资金
- Special Project of 2022 Social Development and Transformation of Scientific and Technological Achievements [51318]
- Zhuzhou Municipal Science and Technology Bureau [30, 44]
- Doctoral Program Construction of Hunan University of Technology, Postgraduates Innovation Fund of HUT
- NSFC [61703152]
- Hunan Provincial Natural Science Foundation [2018JJ34]
- Project of Science and Technology Department of Hunan Province [2021JJ50035]
In this study, a ZrMo2O8-MWCNTs composite was synthesized and used for the electrochemical detection of ADV. The sensor showed a great improvement in the electrochemical response to ADV compared to single-material modified electrodes. It was successfully tested in serum and urine, and demonstrated advantages of simple preparation, fast response, and good reproducibility.
Adefovir (ADV) is an anti-retroviral drug, which can be used to treat acquired immune deficiency syndrome (AIDS) and chronic hepatitis B (CHB), so its quantitative analysis is of great significance. In this work, zirconium molybdate (ZrMo2O8) was synthesized by a wet chemical method, and a composite with multi-walled carbon nanotubes (MWCNTs) was made. ZrMo2O8-MWCNTs composite was dropped onto the surface of a glassy carbon electrode (GCE) to prepare ZrMo2O8-MWCNTs/GCE, and ZrMo2O8-MWCNTs/GCE was used in the electrochemical detection of ADV for the first time. The preparation method is fast and simple. The materials were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and cyclic voltammetry (CV). It was electrochemically analysed by differential pulse voltammetry (DPV). Compared with single-material modified electrodes, ZrMo2O8-MWCNTs/GCE showed a vastly improved electrochemical response to ADV. Moreover, the sensor complements the study of the electrochemical detection of ADV. Under optimal conditions, the proposed electrochemical method showed a wide linear range (from 1 to 100 mu M) and a low detection limit (0.253 mu M). It was successfully tested in serum and urine. In addition, the sensor has the advantages of a simple preparation, fast response, good reproducibility and repeatability. It may be helpful in the potential applications of other substances with similar structures.
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