期刊
MOLECULES
卷 27, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules27196583
关键词
non-biaryl atropisomers; C-N chiral axis; atroposelectivity; catalytic asymmetric synthesis
资金
- Natural Science Foundation of Zhejiang Province in China [LQ21B020006]
This review summarizes the development of catalytic asymmetric synthetic strategies for accessing non-biaryl atropisomers rotating around a C-N chiral axis, including reaction methods, mechanism, late-stage transformations, and applications.
The significant scaffold offered by atropisomeric amides with a C-N chiral axis has been extensively utilized for pharmaceuticals, agricultural science, and organic syntheses. As a result, the field of atropisomer synthesis has attracted considerable interest within chemistry communities. To date, a range of catalytic atroposelective approaches has been reported for the efficient construction of these challenging scaffolds. However, greatly concise and highly useful methodologies for the synthesis of these atropisomeric compounds, focusing on transition-metal, chiral amine, and phosphoric acid catalysis reactions, etc., are still desirable. Hence, it is indispensable to succinctly and systematically present all such reports by means of disclosing the mechanistic analysis and application, as well as the challenges and issues associated with the establishment of these atropisomers. In this review, we summarize the development of catalytic asymmetric synthetic strategies to access non-biaryl atropisomers rotating around a C-N chiral axis, including the reaction methods, mechanism, late-stage transformations, and applications.
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