Quantification of Acipimox in Plasma and Tissues by LC-MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia

Review Endocrinology & Metabolism

Effect of free fatty acids on insulin secretion, insulin sensitivity and incretin effect - a narrative review

Valeria Bahdur Chueire et al.

Summary: The deleterious effects of free fatty acids (FFAs) on insulin sensitivity and secretion are observed in vivo studies. While FFAs are known to impair insulin signaling, their effects on insulin secretion remain controversial, with reports of both inhibition and stimulation depending on various factors. Increased FFAs may decrease insulin biosynthesis and glucose-stimulated insulin secretion. More research is needed to understand the mechanisms behind FFAs' impact on insulin secretion and how to prevent the associated beta-cell impairment and insulin resistance.

ARCHIVES OF ENDOCRINOLOGY METABOLISM (2021)

添加到收藏夹

Article Environmental Sciences

Effects of cold and hot temperature on metabolic indicators in adults from a prospective cohort study

Shan Zheng et al.

Summary: The study found a nonlinear relationship between outdoor temperature and metabolic indicators. In cold effects, a decrease in mean temperature was associated with increases in triglycerides and uric acid, and decreases in HDL-C and LDL-C. In heat effects, an increase in mean temperature was associated with decreases in TC, TG, HDL-C, LDL-C, UA, and FPG. Age, smoking, drinking, high-oil diet, and hyperlipidemia may modify the association between mean temperature and metabolic indicators.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Pharmacokinetics of Acetaminophen and Metformin Hydrochloride in Rats After Exposure to Simulated High Altitude Hypoxia

Jun-bo Zhu et al.

Summary: This study evaluated the pharmacokinetics of acetaminophen and metformin hydrochloride in rats under simulated high altitude hypoxia conditions, revealing significant changes in drug metabolism which may be attributed to decreased gene expression levels.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Critical Care Medicine