期刊
MOLECULES
卷 27, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/molecules27175454
关键词
Codonopsis radix; polysaccharide; immune activity
资金
- National Key R&D Program of China [2019YFC1710800]
- Key R&D Projects of Shanxi Province [201603D3111005]
- Doctoral Research Fund of Shanxi Academy of Agricultural Sciences [YBSJJ1809]
- Academic Recovery Re-search Special Project of Shanxi Agricultural University [2020xshf05]
- earmarked fund for Modern Agro-industry Technology Research System [2021-11]
This study divided Codonopsis radix polysaccharides into different molecular weight groups and evaluated their immunomodulatory effects. The results showed that polysaccharides with different molecular weights have different effects on immune response.
Polysaccharide is one of the main components of Codonopsis radix (CR) and has good immune activity. However, the immune activity of CR polysaccharides with different molecular weights has not been systematically screened. In this study, the polysaccharides of CR from Pingshun of Shanxi Province (PSDSs) were first divided into two groups using ultrafiltration: 3.3 kDa (PSDSs-1) and more than 2000 kDa (PSDSs-2). The immunomodulatory effects of PSDSs with different molecular weights were evaluated in vitro and in vivo. In vitro experimental results showed that compared with Lipopolysaccharide-induced macrophages, PSDSs-1 increased TNF-alpha and IL-6 levels and decreased IL-10. Meanwhile, PSDSs-2 showed the opposite effect, indicating the difference in pro- and anti-inflammatory activities of PSDSs with different molecular weights. The immunosuppressive model of cyclophosphamide proved that PSDSs have immune-promoting function, with PSDSs-1 exhibiting a better effect than PSDSs-2. In vitro and in vivo experiments illustrated the complexity of PSDS immunomodulation. Further research on the functions of PSDs with different molecular weights is needed to lay a foundation for their classification and application.
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