期刊
MOLECULES
卷 27, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules27196381
关键词
pyrazolo[3; 4-b]pyridine; alkyne activation; regional selectivity; 6-endo-dig cyclization
资金
- Science and Technology Innovation Development Plan of Yantai [2020MSGY114]
- Yantai Double Hundred Plan
A cascade 6-endo-dig cyclization reaction has been developed for the switchable synthesis of halogen and non-halogen-functionalized pyrazolo[3,4-b]pyridines. This reaction demonstrated wide substrate scope, good functional group tolerance, and excellent regional selectivity.
A cascade 6-endo-dig cyclization reaction was developed for the switchable synthesis of halogen and non-halogen-functionalized pyrazolo[3,4-b]pyridines from 5-aminopyrazoles and alkynyl aldehydes via C equivalent to C bond activation with silver, iodine, or NBS. In addition to its wide substrate scope, the reaction showed good functional group tolerance as well as excellent regional selectivity. This new protocol manipulated three natural products, and the arylation, alkynylation, alkenylation, and selenization of iodine-functionalized products. These reactions demonstrated the potential applications of this new method.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据