期刊
MOLECULES
卷 27, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules27196448
关键词
vibrational spectroscopy; amyloid oligomers; amyloid intermediates; protein structure; single molecule
资金
- Academia Sinica Investigator Award [AS-IA-109-M04]
- MOST Taiwan [110-2124-M-001-003]
- Air Force Office of Scientific Research [FA9550-21-1-0430, FA2386-21-1-4070]
Amyloid oligomeric species play a significant role in neurodegenerative and metabolic diseases, but studying their structure is challenging due to their low abundance and heterogeneity. Single-molecule techniques have the potential to overcome these challenges.
Amyloid oligomeric species, formed during misfolding processes, are believed to play a major role in neurodegenerative and metabolic diseases. Deepening the knowledge about the structure of amyloid intermediates and their aggregation pathways is essential in understanding the underlying mechanisms of misfolding and cytotoxicity. However, structural investigations are challenging due to the low abundance and heterogeneity of those metastable intermediate species. Single-molecule techniques have the potential to overcome these difficulties. This review aims to report some of the recent advances and applications of vibrational spectroscopic techniques for the structural analysis of amyloid oligomers, with special focus on single-molecule studies.
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