期刊
MOLECULES
卷 27, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules27196668
关键词
maleimides; ketones; succinimides; conjugate addition; organocatalysis; asymmetric synthesis
资金
- Spanish Ministerio de Economia, Industria y Competitividad [PGC2018-096616-B-I00]
- Spanish Ministerio de Ciencia, Innovacion y Universidades [CTQ201788171-P]
- University of Alicante [VIGROB-173]
This study demonstrates the enantioselective synthesis of succinimides by the conjugated addition of ketones to maleimides, catalyzed by a simple primary amine-salicylamide. The reaction gives the desired compounds in good to excellent yields and with moderate to excellent enantioselectivities.
Enantioenriched substituted succinimides are interesting compounds, and their asymmetric organocatalytic synthesis by the conjugated addition of ketones to maleimides has been scarcely explored. This study shows the enantioselective conjugate addition of ketones to maleimides organocatalyzed by a simple primary amine-salicylamide derived from a chiral trans-cyclohexane-1,2-diamine, which provides the desired succinimides in good to excellent yields (up to 98%) and with moderate to excellent enantioselectivities (up to 99%).
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