Predominance of visuoconstructive impairment after mild COVID-19?

Article Behavioral Sciences

Neuropsychological deficits in patients with cognitive complaints after COVID-19

Carmen Garcia-Sanchez et al.

Summary: Subjective cognitive complaints are reported in COVID-19 patients across different disease severities. This study found that attention abilities were widely affected in post-COVID patients with subjective complaints, and were associated with deficits in executive functions, learning, and long-term memory. These cognitive deficits were largely unrelated to clinical factors such as hospitalization and disease duration.

BRAIN AND BEHAVIOR (2022)

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Article Psychiatry

Cognitive dysfunction associated with COVID-19: A comprehensive neuropsychological study

Cristina Delgado-Alonso et al.

Summary: This study found that COVID-19 patients reported lower cognitive performance in attention-concentration and executive functioning, episodic memory, and visuospatial processing. Cognitive function was correlated with olfactory dysfunction and to a lesser extent with sleep quality and anxiety, but not with depression.

JOURNAL OF PSYCHIATRIC RESEARCH (2022)

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Article Multidisciplinary Sciences

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

Gwenaelle Douaud et al.

Summary: Through long-term observation of participants' MRI images, it was found that COVID-19 infection is associated with abnormal brain changes, including a reduction in gray matter thickness in the orbitofrontal cortex and parahippocampal gyrus, greater changes in markers of tissue damage in regions functionally connected to the primary olfactory cortex, and a greater reduction in global brain size. Infected individuals also showed significant cognitive decline.

NATURE (2022)

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Article Biochemistry & Molecular Biology

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

Anthony Fernandez-Castaneda et al.

Summary: COVID survivors may experience lingering neurological symptoms similar to cognitive impairment related to cancer therapy. Research has found that respiratory SARS-CoV-2 infection can cause white-matter-selective microglial reactivity and affect neurogenesis and CCL11 levels.

CELL (2022)

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Review Behavioral Sciences

COVID-19 associated cognitive impairment: A systematic review

Jose W. L. Tavares-Junior et al.

Summary: This study aimed to investigate the relationship between COVID-19 and cognitive impairment. The results showed a wide range of cognitive impairment after COVID-19 infection, with executive functions, attention, and episodic memory being the most affected domains. However, it was unclear whether the cognitive impairment found corresponded to mild cognitive impairment or dementia based on the selected studies, which calls for future research on this topic.

CORTEX (2022)

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Article Immunology