Optimization and Characterization of Low-Molecular-Weight Chitosan-Coated Baicalin mPEG-PLGA Nanoparticles for the Treatment of Cataract

Article Andrology

Epigallocatechin 3-gallate improves the quality of bull semen cryopreservation

Zhiqiang Li et al.

Summary: The study found that adding 0.6 mg/ml of epigallocatechin-3-gallate (EGCG) can improve the quality of frozen bovine semen, enhancing sperm motility and antioxidant capacity while reducing the production of reactive oxygen species.

ANDROLOGIA (2022)

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Article Pharmacology & Pharmacy

Development and optimization of Riluzole-loaded biodegradable nanoparticles incorporated in a mucoadhesive in situ gel for the posterior eye segment

Gerard Esteruelas et al.

Summary: A novel in situ gelling system dispersing RLZ-loaded nanoparticles has been successfully developed as an innovative neuroprotective strategy for potential topical treatment of glaucoma, achieving a more delayed distribution in the posterior eye segment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Chemistry, Medicinal

Corylin from Psoralea fructus (Psoralea corylifolia L.) protects against UV-induced skin aging by activating Nrf2 defense mechanisms

Nan Li et al.

Summary: This study found that corylin can prevent skin aging by inhibiting oxidative stress through the Keap1-Nrf2 signaling pathway. These findings provide evidence for the discovery of novel therapies targeting skin aging.

PHYTOTHERAPY RESEARCH (2022)

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Article Ophthalmology

Comparative evaluation of once-daily and twice-daily dosing of topical bromfenac 0.09%: aqueous pharmacokinetics and clinical efficacy study

Jeewan S. Titiyal et al.

Summary: The study evaluated the aqueous pharmacokinetics of topical bromfenac 0.09% and compared the clinical outcomes of once- and twice-daily dosing in phacoemulsification. Results showed that while single-dose topical bromfenac did not maintain therapeutic aqueous concentration over 24 hours, cumulative effect was observed with repeated dosing. The clinical efficacy of once-daily and twice-daily dosing was comparable.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2021)

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Article Pharmacology & Pharmacy

Topical ocular delivery of vancomycin loaded cationic lipid nanocarriers as a promising and non-invasive alternative approach to intravitreal injection for enhanced bacterial endophthalmitis management

Kamyar Jounaki et al.

Summary: NLCs fabricated VCM carriers can effectively enhance the ocular penetration and residence time of vancomycin, showing significant sustained drug release. The optimized formula significantly increased intravitreal concentration of VCM after ocular administration, showing comparable therapeutic effects to intravitreal injection, with nonirritating and safe profile.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Geriatrics & Gerontology

Development and evaluation studies of Corylin loaded nanostructured lipid carriers gel for topical treatment of UV-induced skin aging

Zhiyue Zhao et al.

Summary: The study showed that Corylin-NLC can significantly suppress LDH release, reduce MDA content, and increase antioxidant enzyme activity in UVB-induced HaCaT cells. The histopathological lesions in mouse serum were significantly improved, with a noticeable decrease in MDA levels. Overall, this research proposes a promising strategy for improving the therapeutic efficacy of photoaging.

EXPERIMENTAL GERONTOLOGY (2021)

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Article Pharmacology & Pharmacy

Study the Antifungal and Ocular Permeation of Ketoconazole from Ophthalmic Formulations Containing Trans-Ethosomes Nanoparticles

Tarek A. Ahmed et al.

Summary: Optimized trans-ethosomal vesicles loaded with ketoconazole were developed in this study to enhance ocular permeation, antifungal activity, and eliminate quickly. The optimized vesicles showed improved characteristics and significantly enhanced antifungal activity of ketoconazole. The in situ gel formulation loaded with these trans-ethosomes vesicles represents a promising ocular delivery system for deep fungal eye infections treatment.

PHARMACEUTICS (2021)

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Article Cell Biology

Toxic effect of titanium dioxide nanoparticles on corneas in vitro and in vivo

Junxing Yang et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

Development of a dual delivery of levofloxacin and prednisolone acetate via PLGA nanoparticles/ thermosensitive chitosan-based hydrogel for postoperative management: An in-vitro and ex-vivo study

Yung-Hsin Cheng et al.

Summary: A novel dual drug delivery system was developed using a thermosensitive chitosan/gelatin-based hydrogel containing prednisolone acetate and levofloxacin-loaded nanoparticles. This system demonstrated sustained release of drugs for 7 days and showed anti-inflammatory and anti-bacterial properties in both ex-vivo and in vivo models, indicating its potential for preventing post-operative endophthalmitis.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Chemistry, Applied

Chitosan coated nanoparticles for efficient delivery of bevacizumab in the posterior ocular tissues via subconjunctival administration

Jayamanti Pandit et al.

Summary: The study evaluated the chitosan-coated poly (lactide-co-glycolic acid) nanoparticles for sustained and effective delivery of bevacizumab to posterior ocular tissues. The results showed better penetration and higher concentration of bevacizumab in posterior ocular tissues, and demonstrated more reduction of VEGF level in retina in a retinopathy model, suggesting the potential utility of CS-coated PLGA NPs as carriers to target the retina.

CARBOHYDRATE POLYMERS (2021)

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Article Ophthalmology

Optimization and Characterization of Brimonidine Tartrate Nanoparticles-loaded In Situ Gel for the Treatment of Glaucoma

Pankaj Kumar Sharma et al.

Summary: The study aimed to develop BRT-PLGA-TPGS nanoparticles in a thermosensitive in situ gel for improved mucoadhesive properties and drug holding capacity in the management of glaucoma. The optimized formulation showed enhanced transcorneal permeability, sustained drug release, and greater reduction in intraocular pressure compared to marketed eye drops. Incorporating the nanoparticles into the gel matrix provided a promising approach for effective glaucoma treatment.

CURRENT EYE RESEARCH (2021)

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Article Pharmacology & Pharmacy

A grafted copolymer-based nanomicelles for topical ocular delivery of everolimus: Formulation, characterization, ex-vivo permeation, in-vitro ocular toxicity, and stability study

Nikita Mehra et al.

Summary: The nanomicellar formulation of everolimus using Soluplus® showed improved permeation and sustained release, leading to enhanced ocular bioavailability for treating uveitis. The nanomicelles exhibited high encapsulation efficiency and deeper permeation through the cornea, suggesting their potential as a promising topical nanocarrier for uveitis treatment.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Ophthalmology

PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage

I-Lun Tsai et al.

Summary: The study demonstrates that using PLGA nanoparticles as a release system for Lingzhi can improve bioavailability and positively impact corneal epithelial cells, reducing inflammation and increasing cell survival rate.

EXPERIMENTAL EYE RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Why chitosan could be apt candidate for glaucoma drug delivery - An overview

B. N. Kumara et al.

Summary: This article highlights the impact of glaucoma on most people worldwide, discusses drug delivery issues in glaucoma treatment, and explores the application value and future prospects of chitosan in this field.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

Fluconazole nanoparticles prepared by antisolvent precipitation technique: Physicochemical, in vitro, ex vivo and in vivo ocular evaluation

Amal El Sayeh F. Abou El Ela et al.

Summary: This research aimed to prepare and characterize nanonized particles of the antifungal drug, fluconazole (FLZ), using antisolvent precipitation nanonization technique to improve its ocular permeation. Different stabilizers were found to impact the nanoparticle size and zeta potential, enhancing the ex vivo release of FLZ and improving its ocular pharmacokinetics. The ophthalmic gel formulations containing FLZ nanoparticles were shown to enhance drug corneal permeation and improve the ocular pharmacokinetic parameters.

SAUDI PHARMACEUTICAL JOURNAL (2021)

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Article Nanoscience & Nanotechnology

Fixed-Combination Eye Drops Based on Fluorometholone Nanoparticles and Bromfenac/Levofloxacin Solution Improve Drug Corneal Penetration

Hiroko Otake et al.

Summary: A fixed-combination eye drops based on FL nanoparticles were prepared to enhance transcorneal penetration of drugs and showed high viability of human corneal epithelial cells. The study revealed that caveolae-dependent endocytosis is related to the enhancement of transcorneal penetration of both solid (NPs) and liquid drugs.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Nanoscience & Nanotechnology

Hyaluronic-Coated Albumin Nanoparticles for the Non-Invasive Delivery of Apatinib in Diabetic Retinopathy

Salma EI-Sayed Radwan et al.

Summary: The study developed hyaluronic acid-coated Apa-loaded bovine serum albumin nanoparticles for the treatment of diabetic retinopathy. These nanoparticles exhibited high EE%, biphasic sustained release profile, and alleviated retinal micro- and ultrastructural changes, indicating a promising platform for enhanced topical therapy of diabetic retinopathy.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Cell Biology

Baicalein, Baicalin, and Wogonin: Protective Effects against Ischemia-Induced Neurodegeneration in the Brain and Retina

Li Pan et al.

Summary: This review focuses on the therapeutic potentials of three major active flavonoids extracted from Scutellaria baicalensis Georgi against ischemia-induced neurotoxicity and damage. These compounds have been shown to have promising pharmacological capabilities in preventing cell and tissue damage, and their bioactivity and bioavailability are also discussed. It is hoped that the therapeutic potential of these flavonoids can be utilized as natural treatments for ischemia-induced injuries of the central nervous system (CNS).

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Biochemistry & Molecular Biology

Nanogel-Facilitated In-Situ Delivery of a Cataract Inhibitor

Dixa Gautam et al.

Summary: Research indicates that inserting a drug-eluting device capable of inhibiting PCO development into the lens capsule post-cataract surgery can significantly prevent cellular changes associated with posterior capsular opacification.

BIOMOLECULES (2021)

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Article Biotechnology & Applied Microbiology

Nanodelivery of triamcinolone acetonide with PLGA-chitosan nanoparticles for the treatment of ocular inflammation

Yi Xing et al.

Summary: The study formulated TA in PLGA-chitosan nanoparticles for the treatment of ocular inflammatory diseases, showing excellent anti-inflammatory activity and symptom alleviation. The PLC-based nanoparticle system exhibited advantages in improving transparency and pharmacokinetics, offering a new approach for ocular inflammation treatment.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Chitosan-Coated PLGA Nanoparticles for Enhanced Ocular Anti-Inflammatory Efficacy of Atorvastatin Calcium

Mona G. Arafa et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Biochemistry & Molecular Biology

Trimethyl chitosan nanoparticles for ocular baicalein delivery: Preparation, optimization, in vitro evaluation, in vivo pharmacokinetic study and molecular dynamics simulation

Jinjing Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Stimulus Responsive Ocular Gentamycin-Ferrying Chitosan Nanoparticles Hydrogel: Formulation Optimization, Ocular Safety and Antibacterial Assessment

Nabil K. Alruwaili et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Nanoscience & Nanotechnology

Evaluation of in vitro and in vivo Efficacy of a Novel Amphotericin B-Loaded Nanostructured Lipid Carrier in the Treatment of Leishmania braziliensis Infection

Jessica Reboucas-Silva et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Biochemistry & Molecular Biology

Leucaena leucocephala (Lam.) galactomannan nanoparticles: Optimization and characterization for ocular delivery in glaucoma treatment

Neeraj Mittal et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Ophthalmology

Preparation and Evaluation of N-Trimethyl Chitosan Nanoparticles of Flurbiprofen for Ocular Delivery

Ujwala A. Shinde et al.

CURRENT EYE RESEARCH (2019)

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Article Pharmacology & Pharmacy

Studying the influence of formulation and process variables on Vancomycin-loaded polymeric nanoparticles as potential carrier for enhanced ophthalmic delivery

Carol Yousry et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Biochemistry & Molecular Biology

Chitosan-based nanoparticles for rosmarinic acid ocular delivery-In vitro tests

Sara Baptista da Silva et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)

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Article Pharmacology & Pharmacy

Nanoparticles in Ocular Drug Delivery Systems for Topical Administration: Promises and Challenges

Hugo Almeida et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

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Article Infectious Diseases

Potential chitosan-coated alginate nanoparticles for ocular delivery of daptomycin

J. R. Costa et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2015)

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Article Pharmacology & Pharmacy

Chitosan nanoparticles for daptomycin delivery in ocular treatment of bacterial endophthalmitis

Nadia C. Silva et al.

DRUG DELIVERY (2015)

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Article Pharmacology & Pharmacy

Preparation and in vitro-in vivo evaluation of ofioxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Neslihan Ustundag-Okur et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

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Article Pharmacology & Pharmacy

Design and characterization of core-shell mPEG-PLGA composite microparticles for development of cell-scaffold constructs

Yanhong Wen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2013)

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Article Biochemistry & Molecular Biology

Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: An in vitro study using isolated lens

R. Manikandan et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2009)

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Article Pharmacology & Pharmacy

Comparative efficacy of pilocarpine, timolol and latanoprost in experimental models of glaucoma

S. K. Gupta et al.

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY (2007)

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Article Chemistry, Multidisciplinary

PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination

Marie Garinot et al.

JOURNAL OF CONTROLLED RELEASE (2007)

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Article Engineering, Biomedical

Ocular drug delivery by liposome-chitosan nanoparticle complexes (LCS-NP)

Yolanda Diebold et al.

BIOMATERIALS (2007)

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Article Pharmacology & Pharmacy

Cytoprotective mechanism of baicalin against endothelial cell damage by peroxynitrite

DH Kim et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2005)

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Article Ophthalmology

Body mass index and age-related cataract - The Shihpai Eye Study

TM Kuang et al.

ARCHIVES OF OPHTHALMOLOGY (2005)

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Article Chemistry, Multidisciplinary

Chitosan nanoparticles as new ocular drug delivery systems:: in vitro stability, in vivo fate, and cellular toxicity

AM de Campos et al.

PHARMACEUTICAL RESEARCH (2004)

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Article Pharmacology & Pharmacy

Effect of chitosan and of N-carboxymethylchitosan on intraocular penetration of topically applied ofloxacin

G Di Colo et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2004)

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Article Pharmacology & Pharmacy

Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings

Y Huang et al.

BIOCHEMICAL PHARMACOLOGY (2004)

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Article Chemistry, Multidisciplinary

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WS Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2004)

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Nanosuspensions: a promising drug delivery strategy

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CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE (2002)

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Optimization and Characterization of Low-Molecular-Weight Chitosan-Coated Baicalin mPEG-PLGA Nanoparticles for the Treatment of Cataract

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