RNA m6A methylation in cancer

N-6-methyladenosine (m(6)A) is one of the most abundant internal modifications in eukaryotic messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs). It is a reversible and dynamic RNA modification that has been observed in both internal coding segments and untranslated regions. Studies indicate that m(6)A modifications play important roles in translation, RNA splicing, export, degradation and ncRNA processing control. In this review, we focus on the profiles and biological functions of RNA m(6)A methylation on both mRNAs and ncRNAs. The dynamic modification of m(6)A and its potential roles in cancer development are discussed. Moreover, we discuss the possibility of m(6)A modifications serving as potential biomarkers for cancer diagnosis and targets for therapy.

Automated summary

This review focuses on the profiles and biological functions of N-6-methyladenosine (m(6)A) modification in eukaryotic RNA, as well as its potential roles in cancer development and as potential targets for therapy and biomarkers for cancer diagnosis.