期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 66, 期 23, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.202200439
关键词
Akkermansia; gut; mice; microbiota; weight
资金
- Edison Biotechnology Institute
- Diabetes Institute at Ohio University (Athens, Ohio, USA)
- French National Research Institute for Sustainable Development (Montpellier, France)
Weight cycling has long-term effects on the composition and function of mouse fecal microbiota, suggesting the need for a long-term approach to fighting weight gain.
Scope Fighting obesity and associated comorbidities through dieting is not always sustained and results in a subsequent weight gain, a phenomenon referred to as weight cycling. Diet is among the most important factors in modifying the composition of gut microbiota. The objective of this work is to determine whether weight cycling affects the composition and the predicted function of mouse fecal bacteria on a long-term basis. Methods and results Mice fed for 40 weeks with either high fat (HF), low fat (LF), or cycled diets (starting and ending by one of the two diets, and the reverse) exhibit a bacterial profile specific to each of the four groups. A higher proportion of Firmicutes and Bacteroidota phyla are observed in mice on Hf and LF diet, respectively. The proportion of functions dedicated to amino acid metabolism is higher in mice on HF or LF/HF diets, whereas the mice on LF or HF/LF diets have a higher proportion of functions involve in carbohydrate metabolism and vitamin B biosynthesis. Conclusion Compared to continuous HF or LF diets, cyclic diet specifically alters the composition and function of the mouse fecal microbiota, suggesting that fight against weight gain should be considered on a long-term basis.
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