期刊
MOLECULAR NEUROBIOLOGY
卷 59, 期 12, 页码 7323-7336出版社
SPRINGER
DOI: 10.1007/s12035-022-03044-6
关键词
Alzheimer's disease; Transplantation; Olfactory mucosa mesenchymal stem cells; Mesenchymal stem cells
资金
- National Natural Science Foundation of China [82172502, 81974127]
- Fundamental Research Funds for the Central Universities of Central South University [2019zzts1042, 2020zzts859]
Alzheimer's disease (AD) is a common neurodegenerative disease that is currently incurable. Transplantation of olfactory mucosa mesenchymal stem cells (OM-MSCs) can alleviate symptoms of AD, promote amyloid-beta clearance, and improve cognitive learning and locomotive behavior.
Alzheimer's disease (AD) is a common neurodegenerative disease that contributes to 60-70% of dementia in elderly people and is currently incurable. Current treatments only relieve the symptoms of AD and slow its progression. Achieving effective neural regeneration to ameliorate cognitive impairment is a major challenge in the treatment of AD. For the first time, we alleviated symptoms of AD in APPswe/PS1dE9 mice (hereafter referred to as AD mice) by transplantation of olfactory mucosa mesenchymal stem cells (OM-MSCs). Our study demonstrated that OM-MSC transplantation promotes amyloid-beta (A beta) clearance, downregulates the inflammatory response, and increases the M2/M1 ratio; OM-MSCs promote the conversion of BV2 (microglia) from M1 to M2 and also A beta clearance in SH-SY5Y(APPswe) (AD cell model). OM-MSC-transplanted AD mice show improved cognitive learning and locomotive behavior. Our study suggests that OM-MSC transplantation could alleviate the symptoms of AD and promote A beta clearance through immunomodulation, thus demonstrating the great potential and social value of OM-MSC treatment for AD patients.
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