期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 59, 期 11, 页码 439-450出版社
WILEY
DOI: 10.1002/jlcr.3430
关键词
fluorine-18; molecular imaging; prostate imaging; radio synthesis
资金
- [CA134675]
- [CA183031]
The radiosynthesis of [F-18]DCFPyL on 2 distinct automated platforms with full regulatory compliant quality control specifications is described. The radiotracer synthesis was performed on a custom-made radiofluorination module and the Sofie Biosciences ELIXYS. The radiofluorination module synthesis was accomplished in an average of 66 minutes from end of bombardment with an average specific activity at end of synthesis (EOS) of 4.4 TBq/mu mol (120 Ci/mu mol) and an average radiochemical yield of 30.9% at EOS. The ELIXYS synthesis was completed in an average of 87 minutes with an average specific activity of 2.2 TBq/mu mol (59.3 Ci/mu mol) and an average radiochemical yield of 19% at EOS. Both synthesis modules produced large millicurie quantities of [F-18]DCFPyL while conforming to all standard US Pharmacopeia Chapter < 823 > acceptance testing criteria.
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