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Quinoline derivatives volunteering against antimicrobial resistance: rational approaches, design strategies, structure activity relationship and mechanistic insights

期刊

MOLECULAR DIVERSITY
卷 27, 期 4, 页码 1905-1934

出版社

SPRINGER
DOI: 10.1007/s11030-022-10537-y

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Quinoline derivatives; Antivirals; Anti-bacterial; Antitubercular; Antileishmanial; Antimalarial; Antifungal

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The emergence of antimicrobial resistance poses a significant threat to the human population due to a lack of development in new antimicrobial agents. Therefore, it is essential to conduct research and develop new novel antimicrobial agents. This review discusses rational approaches, design strategies, structure-activity relationships, and mechanistic insights of newly developed quinoline derivatives as antimicrobial agents.
Emergence of antimicrobial resistance has become a great threat to human species as there is shortage of development of new antimicrobial agents. So, its mandatary to combat AMR by initiating research and developing new novel antimicrobial agents. Among phytoconstituents, Quinoline (nitrogen containing heterocyclic) have played a wide role in providing new bioactive molecules. So, this review provides rational approaches, design strategies, structure activity relationship and mechanistic insights of newly developed quinoline derivatives as antimicrobial agents. [GRAPHICS] .

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