期刊
MOLECULAR BIOLOGY REPORTS
卷 49, 期 9, 页码 9033-9040出版社
SPRINGER
DOI: 10.1007/s11033-022-07839-7
关键词
Drosophila; RNA sequencing; Stress; Transposable elements
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [421255/2018-8]
- Coordenacao de Aperfeicoamento Pessoal de Nivel Superior (CAPES)
This review explores the regulation of transposable element (TE) expression in Drosophila under stress conditions, and finds that stress does not broadly trigger TE transcription. Furthermore, it proposes an explanation for why TE LTR order is the most highly expressed.
Transposable elements, also known as jumping genes, have the ability to hop within the host genome. Nonetheless, this capacity is kept in check by the host cell defense systems to avoid unbridled TE mobilization. Different types of stressors can activate TEs in Drosophila, suggesting that TEs may play an adaptive role in the stress response, especially in generating genetic variability for adaptive evolution. TE activation by stressors may also lead to the notion, usually found in the literature, that any form of stress could activate all or the majority of TEs. In this review, we define what stress is. We then present and discuss RNA sequencing results from several studies demonstrating that stress does not trigger TE transcription broadly in Drosophila. An explanation for the LTR order of TEs being the most overexpressed is also proposed.
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