4.2 Article

Efficacy and safety of anti-TNF multivalent NANOBODY® compound 'ozoralizumab' without methotrexate co-administration in patients with active rheumatoid arthritis: A 52-week result of phase III, randomised, open-label trial (NATSUZORA trial)

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Ozoralizumab, a Humanized Anti-TNFα NANOBODY(R) Compound, Exhibits Efficacy Not Only at the Onset of Arthritis in a Human TNF Transgenic Mouse but Also During Secondary Failure of Administration of an Anti-TNFα IgG

Chihiro Ishiwatari-Ogata et al.

Summary: In this study, we found that ozoralizumab is a promising treatment for rheumatoid arthritis, with low immunogenicity and superior efficacy in secondary failure.

FRONTIERS IN IMMUNOLOGY (2022)

News Item Rheumatology

Ozoralizumab for rheumatoid arthritis

Jennifer Thorley

LANCET RHEUMATOLOGY (2022)

Article Rheumatology

Phase II/III Results of a Trial of Anti-Tumor Necrosis Factor Multivalent NANOBODY Compound Ozoralizumab in Patients With Rheumatoid Arthritis

Tsutomu Takeuchi et al.

Summary: This study assessed the efficacy and safety of ozoralizumab plus methotrexate in patients with active rheumatoid arthritis. The results showed that ozoralizumab significantly reduced the signs and symptoms of RA compared to placebo, with acceptable tolerability.

ARTHRITIS & RHEUMATOLOGY (2022)

Review Radiology, Nuclear Medicine & Medical Imaging

Nanobody: a promising toolkit for molecular imaging and disease therapy

Guangfa Bao et al.

Summary: Nanobodies, as a unique structure of antibodies, have broad prospects for diagnosis and treatment of diseases. They provide high-quality imaging and personalized precision therapy as imaging tracers, and achieve lesion-specific delivery to enhance treatment specificity and efficacy as therapeutic agents.

EJNMMI RESEARCH (2021)

Review Oncology

The Therapeutic Potential of Nanobodies

Ivana Jovcevska et al.

BIODRUGS (2020)

Article Biochemistry & Molecular Biology

Serum albumin-binding VHHs with variable pH sensitivities enable tailored half-life extension of biologics

Henk van Faassen et al.

FASEB JOURNAL (2020)

Article Medicine, General & Internal

Rheumatoid arthritis

Josef S. Smolen et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Review Immunology

Single-Domain Antibodies or Nanobodies: A Class of Next-Generation Antibodies

Farnaz Khodabakhsh et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2018)

Article Rheumatology

Cytokines in rheumatoid arthritis - shaping the immunological landscape

Iain B. McInnes et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Review Immunology

Treatment of rheumatoid arthritis: Unraveling the conundrum

Evangelia Zampeli et al.

JOURNAL OF AUTOIMMUNITY (2015)

Review Rheumatology

The Japanese experience with biologic therapies for rheumatoid arthritis

Tsutomu Takeuchi et al.

NATURE REVIEWS RHEUMATOLOGY (2010)

Review Immunology

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

Janusz Wesolowski et al.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2009)

Review Biotechnology & Applied Microbiology

Properties, production, and applications of camelid single-domain antibody fragments

M. M. Harmsen et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2007)

Article Biochemistry & Molecular Biology

Albumin binding as a general strategy for improving the pharmacokinetics of proteins

MS Dennis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)