期刊
MICROCHEMICAL JOURNAL
卷 180, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.microc.2022.107567
关键词
DEHP metabolite; 2-Ethylhexanol; 4-Heptanone; Multiple headspace solid-phase micro-extraction (MHS-SPME); Human urine
资金
- University of the Basque Country (UPV/EHU) [GIU19/068]
- University of Basque Country (UPV/EHU)
In this study, an analytical method for determining two plasticizer metabolites in urine was optimized and validated. The results showed significantly increased levels of 2-ethylhexanol in urine samples of volunteers in the early hours after receiving blood transfusion.
In the present work, an optimization and validation of an analytical method for the determination of two plasticizer metabolites, 2-ethylhexanol and 4-heptanone in urine, were carried out by multiple headspace solid-phase microextraction (MHS-SPME) coupled to GC-MS. The validation study was successfully performed in terms of stability, method selectivity, linearity, accuracy, recovery, intermediate precision, repeatability, limit of detection (LOD) and limit of quantification (LOQ) in urine samples. Finally, two population group studies were developed in urine samples of volunteers with plastic exposure. First group represents the common plastic exposure of general population and the second one was carried out with healthy moderately trained individuals who have received blood transfusion. This study demonstrates that significantly increased levels of 2-ethylhexanol were found (p < 0.05) in urine samples of volunteers in the early hours after receiving blood transfusion.
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