4.7 Article

Improvement strategies on colorimetric performance and practical applications of Paper-based analytical devices

期刊

MICROCHEMICAL JOURNAL
卷 180, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.microc.2022.107562

关键词

Paper-based analytical devices (PADs); Colorimetric performance improvement; Paper surface modifications; Assaying system selection for PADs; Image treatment methods; Practical applications

资金

  1. Monash Institute of Medical Engineering (MIME) for MIME-SPARK funds
  2. Australian Research Council for the funding support through the Research Hub for Energy Efficient Separation Project [IH170100009]
  3. Department of Industry, Innovation and Science for research funds through Innovation Connections Projects [ICG000457, ICG000830]
  4. National Research Council of Thailand [NRCT5-RSA63023-01, N11A650144]
  5. Australian Research Council Grant [LE180100043]
  6. Australian Research Council [LE180100043] Funding Source: Australian Research Council

向作者/读者索取更多资源

Colorimetric paper-based analytical devices (PADs) are widely used for on-site analysis due to their ease of construction and compatibility with low-cost imaging devices. However, the sensitivity and color quality of paper limit the further improvement of PADs. This review summarizes strategies for enhancing the colorimetric performance of PADs, including controlling liquid-paper interaction, assessing paper environment, and improving image capture techniques. The review also highlights designs that enhance the portability of PADs.
Colorimetric paper-based analytical devices (PADs) have been widely fabricated due to the ease of construction of colorimetric reactions on paper and the high compatibility with low-cost and easy-to-use imaging devices for on-site analysis and results recording. However, the further advance of colorimetric PADs is limited by the detection sensitivity and other intrinsic limitations of paper regarding the color quality. This review summarizes the strategies for improving the colorimetric performances (color intensity and uniformity) of PADs. In particular, the principles of controlling liquid-paper interaction for the color intensity enhancement, developed in printing research, are discussed in relation to PAD designs. The influence of the paper assaying environment to the paper assaying selectivity is discussed through a case study for the first time. Image capture techniques and image process algorithms are related to the accuracy and sensitivity of the colored results, which are carefully introduced. Finally, based on the tendency of improvement of colorimetric PADs for practical applications, we summarized the designs that enhance the portability of colorimetric PADs. It is believed that the new links and opinions provided in this review may be useful to researchers to address the challenges in designing future colorimetric PADs with improved sensitivities for field use.

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