期刊
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
卷 86, 期 4, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/mmbr.00181-21
关键词
vaginal microbiome; cervical microbiome; uterine microbiome; female reproductive tract; upper genital tract; Lactobacillus; bacterial vaginosis; vaginitis; pregnancy; preterm birth
类别
资金
- National Institutes of Health [UH3AI083263, U54HD080784, R01HD092415]
- GAPPS BMGF PPB grant from the Global Alliance to Prevent Prematurity and Stillbirth
The microbiome of the female reproductive tract has a unique biodiversity, with a homogeneous Lactobacillus-based microbiome associated with health and other taxa associated with dysbiosis and disease. Recent research efforts have focused on understanding how these microorganisms influence gynecologic and reproductive health.
The microbiome of the female reproductive tract defies the convention that high biodiversity is a hallmark of an optimal ecosystem. Although not universally true, a homogeneous vaginal microbiome composed of species of Lactobacillus is generally associated with health, whereas vaginal microbiomes consisting of other taxa are generally associated with dysbiosis and a higher risk of disease. The microbiome of the female reproductive tract defies the convention that high biodiversity is a hallmark of an optimal ecosystem. Although not universally true, a homogeneous vaginal microbiome composed of species of Lactobacillus is generally associated with health, whereas vaginal microbiomes consisting of other taxa are generally associated with dysbiosis and a higher risk of disease. The past decade has seen a rapid advancement in our understanding of these unique biosystems. Of particular interest, substantial effort has been devoted to deciphering how members of the microbiome of the female reproductive tract impact pregnancy, with a focus on adverse outcomes, including but not limited to preterm birth. Herein, we review recent research efforts that are revealing the mechanisms by which these microorganisms of the female reproductive tract influence gynecologic and reproductive health of the female reproductive tract.
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