4.5 Review

The role of excitatory amino acid transporter 2 (EAAT2) in epilepsy and other neurological disorders

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function

Peter Kovermann et al.

Summary: Mutations in the gene SLC1A2 encoding the excitatory amino acid transporter 2 (EAAT2) are associated with severe forms of epileptic encephalopathy. Mutations G82R and L85P contribute to the formation of an anion pore in EAAT2, allowing glutamate efflux, while mutation P289R decreases glutamate uptake but increases anion currents, leading to glutamate excitotoxicity and neuronal hyperexcitability in affected patients. Therapeutic agents targeting the EAAT anion channel function could be beneficial in the future.

EPILEPSIA (2022)

Article Neurosciences

Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity

Adriana L. Hotz et al.

Summary: The loss of function in the astroglia predominant eaat2a gene in zebrafish leads to altered neuronal and astroglial networks, resulting in epileptic seizures and increased extracellular glutamate levels. Interestingly, while hyperexcitability is observed during seizures, basal neuronal and astroglial activity is reduced, leading to decreased overall locomotion in eaat2a(-/-) mutant animals.
Article Genetics & Heredity

SLC gene mutations and pediatric neurological disorders: diverse clinical phenotypes in a Saudi Arabian population

Ali Mir et al.

Summary: The article discusses the prevalence of SLC gene mutations in children with epilepsy and other neurological disorders, highlighting the diverse phenotypes associated with mutations in this large family of SLC transporter proteins, and the opportunity for personalized genomics and personalized therapeutics.

HUMAN GENETICS (2022)

Article Neurosciences

Induction of Parkinsonian-Like Changes via Targeted Downregulation of Astrocytic Glutamate Transporter GLT-1 in the Striatum

Chao Ren et al.

Summary: This study found that knocking down astrocytic GLT-1 could lead to PD-like changes, including impaired motor function, abnormal gait, and depression-like features. Additionally, the dopaminergic system was impaired and the count of tyrosine hydroxylase (TH) positive neurons was reduced in astrocytic GLT-1 knockdown rats. Blocking glutamate excitotoxicity may provide a new strategy for the prevention and treatment of PD.

JOURNAL OF PARKINSONS DISEASE (2022)

Article Psychiatry

Polymorphism of rs12294045 in EAAT2 gene is potentially associated with schizophrenia in Chinese Han population

Lina Wang et al.

Summary: This study investigated the relationship between the polymorphism of EAAT1 and EAAT2 genes and schizophrenia in Chinese Han population. The results showed a significant difference in allelic distributions between cases and controls at the rs12294045 locus of EAAT2 gene. Additionally, the polymorphism was associated with family history and cognitive deficits in patients.

BMC PSYCHIATRY (2022)

Review Biochemistry & Molecular Biology

Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission

Martina Montanari et al.

Summary: Disturbances in the glutamatergic system have been observed in autism spectrum disorder (ASD). This review summarizes evidence from patient samples, postmortem studies, and animal models to explore the role of glutamate in the pathophysiology of ASD and its potential as a therapeutic target.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Physiology

Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy

Hsin-Hua Li et al.

Summary: The study investigated the combined effects of ceftriaxone and valproic acid on behavioral and neuronal measures in a rat epilepsy model. It was found that the combination of low doses of ceftriaxone and valproic acid had beneficial effects on seizure suppression, neuroprotection, and improvement in motor and cognitive functions in epilepsy.

EXPERIMENTAL PHYSIOLOGY (2021)

Article Multidisciplinary Sciences

GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS

Natsuko Ohashi et al.

Summary: This study investigated the use of bone marrow-derived cells (BMDCs) as gene carriers for cell-based gene therapy in treating ALS mice. By infecting BM cells with lentiviral vectors expressing GLT1, which protects neurons from glutamate toxicity, and transplanting them into ALS mice, the treated mice showed improvement in motor behaviors and prolonged survival. Results indicated that the expression of GLT1 by BMDCs improved the spinal cord environment, suggesting a potential gene therapy strategy for treating neurodegenerative diseases like ALS.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Ceftriaxone pretreatment confers neuroprotection in rats with acute glaucoma and reduces the score of seizures induced by pentylenotetrazole in mice

Helene A. Fachim et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)

Article Medicine, Research & Experimental

Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity

Longze Sha et al.

THERANOSTICS (2020)

Review Pharmacology & Pharmacy

Targeting metabotropic glutamate receptors in the treatment of epilepsy: rationale and current status

Roberta Celli et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

Article Clinical Neurology

Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism

Andrew B. Stergachis et al.

ANNALS OF NEUROLOGY (2019)

Review Physiology

Glutamate Transport and Preterm Brain Injury

Silvia Pregnolato et al.

FRONTIERS IN PHYSIOLOGY (2019)

Article Neurosciences

Regulation of Synaptosomal GLT-1 and GLAST during Epileptogenesis

Allison R. Peterson et al.

NEUROSCIENCE (2019)

Review Pharmacology & Pharmacy

Epigenetic Regulation of Excitatory Amino Acid Transporter 2 in Neurological Disorders

Mohammad Afaque Alam et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Spinal cord-specific deletion of the glutamate transporter GLT1 causes motor neuron death in mice

Kaori Sugiyama et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Neurosciences

Neurotransmitters in the mediation of cerebral ischemic injury

Diana Mayor et al.

NEUROPHARMACOLOGY (2018)

Article Geriatrics & Gerontology

Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies

Paula Garcia-Esparcia et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex

Binkai Chi et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy

Jan Albrecht et al.

NEUROCHEMICAL RESEARCH (2017)

Article Genetics & Heredity

De Novo Mutations in YWHAG Cause Early-Onset Epilepsy

Ilaria Guella et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Review Biochemistry & Molecular Biology

Lessons learned from gene identification studies in Mendelian epilepsy disorders

Katia Hardies et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2016)

Article Genetics & Heredity

De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies

Candace T. Myers et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2016)

Review Biochemistry & Molecular Biology

Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease

Kou Takahashi et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

Article Pharmacology & Pharmacy

Targeting metabotropic glutamate receptors (mGluRs) in Parkinson's disease

Marianne Amalric

CURRENT OPINION IN PHARMACOLOGY (2015)

Article Pharmacology & Pharmacy

Targeting glutamatergic synapses in Parkinson's disease

Fabrizio Gardoni et al.

CURRENT OPINION IN PHARMACOLOGY (2015)

Article Medicine, Research & Experimental

Glutamatergic Mechanisms Associated with Seizures and Epilepsy

Melissa Barker-Haliski et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

Article Genetics & Heredity

De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies

Silke Appenzeller et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2014)

Article Medicine, Research & Experimental

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

Qiongman Kong et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Biochemistry & Molecular Biology

Differential regulation of the glutamate transporters GLT-1 and GLAST by GSK3β

Esperanza Jimenez et al.

NEUROCHEMISTRY INTERNATIONAL (2014)

Review Physiology

SLC1 glutamate transporters

Christof Grewer et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2014)

Article Pharmacology & Pharmacy

Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia

Marco Spangaro et al.

PHARMACOGENOMICS (2014)

Review Biochemistry & Molecular Biology

Glutamate, Glutamate Receptors, and Downstream Signaling Pathways

Stacey S. Willard et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2013)

Article Multidisciplinary Sciences

De novo mutations in epileptic encephalopathies

Andrew S. Allen et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Glutamate transporter expression and function in a striatal neuronal model of Huntington's disease

Geraldine T. Petr et al.

NEUROCHEMISTRY INTERNATIONAL (2013)

Review Physiology

MECHANISMS OF GLUTAMATE TRANSPORT

Robert J. Vandenberg et al.

PHYSIOLOGICAL REVIEWS (2013)

Review Public, Environmental & Occupational Health

Manganese Neurotoxicity: a Focus on Glutamate Transporters

Pratap Karki et al.

ANNALS OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2013)

Article Chemistry, Medicinal

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

Chien-Liang Glenn Lin et al.

FUTURE MEDICINAL CHEMISTRY (2012)

Review Neurosciences

Astrocytic regulation of glutamate homeostasis in epilepsy

Douglas A. Coulter et al.

Article Neurosciences

Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP

Juan D. Pita-Almenar et al.

LEARNING & MEMORY (2012)

Article Neurosciences

GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model

Paramita Mookherjee et al.

JOURNAL OF ALZHEIMERS DISEASE (2011)

Article Geriatrics & Gerontology

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

Heather A. Scott et al.

NEUROBIOLOGY OF AGING (2011)

Article Clinical Neurology

Aberrant Detergent-Insoluble Excitatory Amino Acid Transporter 2 Accumulates in Alzheimer Disease

Randall L. Woltjer et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)

Letter Biochemical Research Methods

A method and server for predicting damaging missense mutations

Ivan A. Adzhubei et al.

NATURE METHODS (2010)

Article Neurosciences

Blockade of Astrocytic Glutamate Uptake in Rats Induces Signs of Anhedonia and Impaired Spatial Memory

Anita J. Bechtholt-Gompf et al.

NEUROPSYCHOPHARMACOLOGY (2010)

Review Pharmacology & Pharmacy

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

Stephen F. Traynelis et al.

PHARMACOLOGICAL REVIEWS (2010)

Article Pharmacology & Pharmacy

Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1

Elena Fumagalli et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

Article Biochemistry & Molecular Biology

Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes

Seok-Geun Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

The Yin and Yang of YY1 in the nervous system

Ye He et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Valproate-dependent transcriptional regulation of GLAST/EAAT1 expression:: Involvement of Ying-Yang 1

Gisela Aguirre et al.

NEUROCHEMISTRY INTERNATIONAL (2008)

Review Pharmacology & Pharmacy

Transporters for L-glutamate: An update on their molecular pharmacology and pathological involvement

P. M. Beart et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Review Biochemistry & Molecular Biology

EAAT2 regulation and splicing: relevance to psychiatric and neurological disorders

T. L. Lauriat et al.

MOLECULAR PSYCHIATRY (2007)

Review Biochemistry & Molecular Biology

The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention

Amanda L. Sheldon et al.

NEUROCHEMISTRY INTERNATIONAL (2007)

Article Neurosciences

Paradoxical Upregulation of Glutamatergic presynaptic boutons during mild cognitive impairment

Karen F. S. Bell et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Neurosciences

Anti-glutamatergic effect of riluzole: Comparison with valproic

J.-E. Kim et al.

NEUROSCIENCE (2007)

Article Genetics & Heredity

Mapping autism risk loci using genetic linkage and chromosomal rearrangements

Peter Szatmari et al.

NATURE GENETICS (2007)

Article Biochemistry & Molecular Biology

Caspase-3 cleaves and inactivates the glutamate transporter EAAT2

William Boston-Howes et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Clinical Neurology

Extracellular metabolites in the cortex and hippocampus of epileptic patients

I Cavus et al.

ANNALS OF NEUROLOGY (2005)

Article Genetics & Heredity

Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors

WE Kaufmann et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2004)

Review Neurosciences

Molecular pharmacology of glutamate transporters, EAATs and VGLUTs

Y Shigeri et al.

BRAIN RESEARCH REVIEWS (2004)

Review Biochemistry & Molecular Biology

Excitatory amino acid transporters: keeping up with glutamate

SG Amara et al.

NEUROCHEMISTRY INTERNATIONAL (2002)

Article Multidisciplinary Sciences

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

DS Howland et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity

D Trotti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)