期刊
CARBOHYDRATE POLYMERS
卷 115, 期 -, 页码 715-722出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.07.063
关键词
Cellulose; Drug delivery; Microparticles; Nanowhiskers; Starch
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES/PNPD)
- CNPq
- CAPES
- Instituto de Ciencia, Tecnologia e Inovacao em Materiais Complexos Funcionais (INO-MAT)
- Fundacao Araucaria - Brasil
This work describes the preparation of a microhydrogel composite from cellulose nanowhiskers (CNW) and starch in an ultrasound assisted-emulsion. CNW, which showed rod-like morphology, was obtained by acid hydrolysis of cane-based cellulose. The introduction of vinyl bonds to both CNW and starch enabled us to create the microhydrogel composite in which CNW played a role as a covalent crosslinker. Furthermore, CNW may act as an emulsifying agent for emulsion, improving both sphericity and homogeneity of the microparticles. The drug release was regulated in response to changes in the CNW amounts. The modeling of the release kinetics indicated that the drug release is driven by an anomalous mechanism and that the addition of CNW to starch microparticles led to differences in that mechanism. The release rate became ca. 2.9 times slower when CNW is added. When combined with starch, CNW played a role as a retardant factor for drug release. (C) 2014 Elsevier Ltd. All rights reserved.
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