期刊
MEDICAL ENGINEERING & PHYSICS
卷 108, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2022.103886
关键词
Carotid ultrasound; Atherosclerosis; Viscoelasticity; Wall motion; Transfer function; Plaque burden
资金
- [NRF-2020R1A2C1004354]
This study estimated the viscoelastic parameters of blood vessels using ultrasound images and pressure waveforms, and found a correlation between viscous parameters and arterial plaques. This suggests that viscous parameters may serve as a new mechanical index for early detection of atherosclerosis.
Viscoelasticity may be an important physical index for diagnosing vascular diseases, but wall viscosity has received less attention than elasticity due to difficulties in measurement in clinical scenarios. In this study, viscoelastic parameters were estimated from the pressure diameter relationship using carotid artery ultrasound images and brachial artery pressure waveforms of the patients. Carotid artery diameter waveforms were obtained by analyzing wall motion in ultrasound cine images, and carotid pressure waveforms were estimated from brachial waveforms using a transfer function. The estimated viscoelastic parameters quantitatively agreed with the published data, and three viscous parameters (viscous index, energy dissipation ratio, and phase lag between pressure and diameter waveforms) showed good positive correlations with each other. No significant difference in wall elasticity was found between the no plaque (NP) and low plaque (LP) groups, whereas viscous parameters were lower in the NP group than the LP group. This result suggests that the viscous parameters may be a new mechanical index for detecting early atherosclerosis.
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