期刊
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
卷 60, 期 12, 页码 3585-3600出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11517-022-02683-0
关键词
Electroporation; Electrofusion; Ultra-shorted pulsed electric field; Transmembrane potential; Pore radius
类别
资金
- Science, Technology & Innovation Funding Authority (STDF)
- Egyptian Knowledge Bank (EKB)
- Zewail City of Science and Technology, AUC
This paper uses a finite element mathematical model to study electroporation and electrofusion, and improves the mathematical models by analyzing the distribution, radius, and density of pores. The results show that nanosecond pulses can avoid the effect of cell size on electrofusion and have larger pore radius at the contact point between cells.
An electric pulse with a sufficient amplitude can lead to electroporation of intracellular organelles. Also, the electric field can lead to electrofusion of the neighboring cells. In this paper, a finite element mathematical model was used to simulate the distribution, radius, and density of the pores. We simulated a mathematical model of the two neighbor cells to analyze the fluctuation in the electroporation parameters before the electrofusion under the ultra-shorted electric field pulse (i.e., impulse signal) for each cell separately and after the electrofusion under the ultra-shorted pulse. The analysis of the temporal and spatial distribution can lead to improving the mathematical models that are used to analyze both electroporation and electrofusion. The study combines the advantages of the nanosecond pulse to avoid the effect of the cell size on the electrofusion and the large-pore radius at the contact point between the cells.
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