期刊
CARBOHYDRATE POLYMERS
卷 131, 期 -, 页码 57-64出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.05.021
关键词
Alginate; Hydrogel; Ionic cross-linking; Iron; Photochemistry
资金
- National Science Foundation [CHE 1150768]
Calcium cross-linked alginate hydrogels are widely used in targeted drug delivery, tissue engineering, wound treatment, and other biomedical applications. We developed a method for preparing homogeneous alginate hydrogels cross-linked with Ca2+ cations using reductive cation exchange in homogeneous iron(III) cross-linked alginate hydrogels. Treatment of iron(III) cross-linked alginate hydrogels with calcium salts and sodium ascorbate results in reduction of iron(III) cations to iron(II) that are instantaneously replaced with Ca2+ cations, producing homogeneous ionically cross-linking hydrogels. Alternatively, the cation exchange can be performed by photochemical reduction in the presence of calcium chloride using a sacrificial photoreductant. This approach allows fabrication of patterned calcium alginate hydrogels through photochemical patterning of iron(III) cross-linked alginate hydrogel followed by the photochemical reductive exchange of iron cations to calcium. (C) 2015 Elsevier Ltd. All rights reserved.
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