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Osteoarthritis: The importance of hormonal status in midlife women

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Article Orthopedics

Female reproductive factors and risk of joint replacement arthroplasty of the knee and hip due to osteoarthritis in postmenopausal women: a nationwide cohort study of 1.13 million women

Y. Eun et al.

Summary: This study aimed to explore the relationships between reproductive factors and joint replacement arthroplasty of the knee and hip in postmenopausal Korean women. The results showed that later age at menarche, longer breastfeeding, hormone replacement therapy, and oral contraceptive use were associated with increased risk of severe OA-related surgeries, while later age at menopause and longer reproductive span were associated with decreased risk. The associations between reproductive factors and severe OA were more pronounced in underweight and younger subjects.

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Summary: This study found no significant clinical associations between reproductive factors and OA, potentially due to complex hormonal effects. Further investigation in prospective cohort studies is needed.

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