期刊
MATHEMATICAL BIOSCIENCES
卷 352, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mbs.2022.108899
关键词
Systems biology; Bond graph; Energy-based; Photosynthesis; Electrochemical transduction
资金
- School of Mathematics and Statistics, University of Melbourne, Australia
- Faculty of Engineering and Information Technology, University of Melbourne, Australia
This paper summarises the significant contributions of Edmund Crampin and his group in applying energy-based bond graph methods to biological systems. It motivates the importance of considering energy in biological modelling, introduces bond graphs as a methodology, describes extensions for modelling electrochemical transduction, outlines modular construction of bond graph models, and explains stoichiometric approaches for deriving fundamental properties of reaction networks.
Edmund Crampin (1973-2021) was at the forefront of Systems Biology research and his work will influence the field for years to come. This paper brings together and summarises the seminal work of his group in applying energy-based bond graph methods to biological systems. In particular, this paper: (a) motivates the need to consider energy in modelling biology; (b) introduces bond graphs as a methodology for achieving this; (c) describes extensions to modelling electrochemical transduction; (d) outlines how bond graph models can be constructed in a modular manner and (e) describes stoichiometric approaches to deriving fundamental properties of reaction networks. These concepts are illustrated using a new bond graph model of photosynthesis in chloroplasts.
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