期刊
MATERIALS & DESIGN
卷 223, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2022.111193
关键词
Polyether ether ketone; Hydroxyapatite; Bionic; Porous; Implants; Osseointegration
资金
- Key Projects of Military Logistics Opening Research [BLB20J011]
- Jilin Scientific and Technological Development Program [20210402025GH]
- Dengfeng Projects of Foshan Hospital of Chinese Traditional Medicine [202100044]
- National Natural Science Foundation of China [52173146]
Porous polyether ether ketone (PEEK) scaffolds with hydroxyapatite (HA) layer coated on the pore wall surface were prepared using a sacrificial porogen of HA-coated sodium chloride (NaCl) microspheres. The PEEK@HA scaffolds exhibited superior in vitro biomineralization and in vivo osseointegration, providing a facile manufacturing strategy for integratedly fabricating bio-nic porous PEEK scaffolds with a mineralized coating layer.
Porous polyether ether ketone (PEEK) scaffolds with hydroxyapatite (HA) layer coated on the pore wall surface were prepared using sacrificial porogen of HA-coated sodium chloride (NaCl) microspheres. The manufacture of bionic porogen was structurally inspired by the Chinese traditional food Matuan, which is a glutinous rice ball stuck with sesames. Spherical-shaped NaCl@HA microspheres with a uni-form size facilitated the generation of an interconnected porous PEEK@HA scaffold with a HA coating layer on the pore surface. And the mechanical properties of PEEK@HA scaffolds were not affected by the coating layer of HA compared with PEEK porous scaffolds. After immersing in simulated body fluid and transplanting in rat proximal tibia, the PEEK@HA porous implants possessed superior in vitro biomineralization and in vivo osseointegration due to the favorable environment of the HA layer for bone ingrowth. This facile manufacturing strategy provides a unique perspective to integratedly fabricate bio-nic porous PEEK scaffolds with a mineralized coating layer enhancing the osseointegration of PEEK mate-rials with bony tissue interfaces in orthopedics and stomatology. It also presents a general platform for further creating multifunctional porous PEEK implants, such as antibacterial, immunomodulatory, and photothermal therapy, by coating various inorganic nanoparticles with desired characteristics on the pore wall surface.(c) 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
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