期刊
MATERIALS & DESIGN
卷 221, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2022.110894
关键词
Curcumin; Electrospray; Nano-in-micro; Macrophage-targeting; Ulcerativecolitis
资金
- China Postdoctoral Science Foundation [2021M690488]
- National Interdisciplinary Innovation Team of Traditional Chinese Medicine [ZYYCXTD-D-202209]
A novel oral nano-in-micro system was developed for efficient colonic delivery of curcumin (Cur). The system consisted of hyaluronic acid (HA)/zein complex nanoparticles (NPs) loaded with Cur, embedded in alginate/chitosan hydrogel microparticles (Cur@NMPs). The system showed sustained drug release and bio-adhesiveness, and significantly alleviated colitis symptoms.
Although nano-systems can promote the cellular internalization, polymeric nanoparticles (NPs) are easily to be destroyed or eliminated in the gastrointestinal tract, which leads to premature drug release or insufficient colonic accumulation. A novel oral nano-in-micro system for the efficient colonic delivery of curcumin (Cur) was developed in this study, in which the hyaluronic acid (HA)/zein complex NPs loading Cur were embedded in alginate/chitosan hydrogel microparticles (Cur@NMPs) with the electrospray technology. The Cur@NMPs showed uniform-sized sphere with an average size of 218.36 +/- 10 mu m, encapsulating Cur@HA/zein NPs with the average size of 148.64 +/- 3.21 nm. Cur in NMPs showed the sustained drug-release profiles in simulated gastric fluid, whereas it showed the rapid release in simulated colonic fluid. Mediated by the HA-CD44 receptor recognition, Cur@HA/zein NPs had the increased cellular uptake efficiency in macrophages. Furthermore, NMPs had the significant colon-retention and bio-adhesiveness capacity in colon tissues. As expected, the oral administration of Cur@NMPs significantly mitigated colitis symptoms in DSS-induced UC mice by inhibiting TLR4/NF-kappa B pathway. The above results can provide a useful drug delivery strategy for Cur in the treatment of UC by retaining the advantages of nano- and micro-scaled carriers. (C) 2022 Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据