期刊
CARBOHYDRATE POLYMERS
卷 132, 期 -, 页码 351-358出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.06.057
关键词
Bacterial cellulose; Silver sulfadiazine; Sodium alginate; Antibacterial activity
资金
- National Natural Science Foundation of China [51401109]
- Natural Science Foundation of Jiangsu Higher Education of China [14KJB430018]
- High-level Talent Project of Nanjing Forestry University [GXL201301]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Sodium alginate (SA) and bacterial cellulose (BC) are widely used in many applications such as scaffolds and wound dressings due to its biocompatibility. Silver sulfadiazine (AgSD) is a topical antibacterial agents used as a topical cream on burns. In the study, novel BC/SA-AgSD composites were prepared and characterized by SEM, FTIR and TG analyses. These results indicate AgSD successfully impregnated into BC/SA matrix. The swelling behaviors in different pH were studied and the results showed pH-responsive swelling behaviors. The antibacterial performances of BC/SA-AgSD composites were evaluated with Escherichia coli, Staphylococcus aureus and Candida albicans. Moreover, the cytotoxicity of BC/SA-AgSD composites was performed on HEK 293 cells. The experimental results showed BC/SA-AgSD composites have excellent antibacterial activities and good biocompatibility, thus confirming its utility as potential wound dressings. (C) 2015 Elsevier Ltd. All rights reserved.
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