期刊
MARINE DRUGS
卷 20, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/md20090583
关键词
isocoumarins; polyketides; anti-inflammatory activity; Penicillium sp
资金
- National Natural Science Foundation of China [41876153]
- Guangdong Marine Economy Development Special Project [[2022]35]
Four new polyketide compounds and two new citreoviridin derivatives were isolated from the mangrove endophytic fungus Penicillium sp. BJR-P2. Compound 2 exhibited stronger anti-inflammatory activity by inhibiting NO production induced by LPS.
Four new polyketide compounds, including two new unique isocoumarins penicillol A (1) and penicillol B (2) featuring with spiroketal rings, two new citreoviridin derivatives citreoviridin H (3) and citreoviridin I (4), along with four known analogues were isolated from the mangrove endophytic fungus Penicillium sp. BJR-P2. Their structures were elucidated by extensive spectroscopic methods. The absolute configurations of compounds 1-4 based on electronic circular dichroism (ECD) calculations, DP4+ analysis, and single-crystal X-ray diffraction are presented. All the new compounds were evaluated for anti-inflammatory activity. An anti-inflammatory assay indicated that compound 2 inhibited lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells, with half-maximal inhibitory concentration (IC50) values of 12 mu M, being more potent than the positive control, indomethacin (IC50 = 35.8 +/- 5.7 mu M). Docking study showed that compound 2 was perfectly docking into the active site of murine inducible nitric oxide oxygenase (iNOS) via forming multiple typical hydrogen bonds.
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