期刊
MARINE DRUGS
卷 20, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/md20080529
关键词
Talaromyces minioluteus; Gigantidas platifrons; deep-sea cold seep; antimicrobial activity; DPPH scavenging activity
资金
- Strategic Priority Research Program of Chinese Academy of Sciences [XDA22050401]
- National Natural Science Foundation of China [U2006203, 82003648, KEXUE2020GZ02]
Five new aromatic polyketides, including a unique benzofuran derivative, talarominine A (1), and four chromone analogs talamins A-D (2-5), were isolated and identified from the endozoic fungus Talaromyces minioluteus CS-138 obtained from the deep-sea cold seep mussel Gigantidas platifrons. The chemical structures of these compounds were elucidated and their antibacterial and DPPH scavenging activities were evaluated, showing promising bioactivities. This work represents the first report on marine natural products of mussel-derived fungus living in cold seep environments.
Five new aromatic polyketides, including a unique benzofuran derivative, talarominine A (1), and four chromone analogs talamins A-D (2-5), along with one known related metabolite, 5-hydroxy-7-methoxy-2,3-dimethylchromone (6), were isolated and identified from the Talaromyces minioluteus CS-138, an endozoic fungus obtained from the deep-sea cold seep mussel Gigantidas platifrons. Their chemical structures were elucidated by detailed analysis of their NMR spectra, HRESIMS and X-ray crystallographic data, and by comparison with literature data as well. The antibacterial and DPPH scavenging activities of compounds 1-6 were evaluated. Compounds 1-3 showed inhibitory activity against some of the tested bacteria whereas compounds 2 and 5 showed potent DPPH radical scavenging activities, which were better than that of the positive control butylated hydroxytoluene (BHT). This work is likely the first report on marine natural products of mussel-derived fungus living in cold seep environments.
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