期刊
MARINE DRUGS
卷 20, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/md20110664
关键词
fish scales; marine collagen; acid-soluble collagen; pepsin-soluble collagen; nanofibers
资金
- European Union
- Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation under the call RESEARCH-CREATE-INNOVATE [T1EDK-02509]
By comparing the collagen content of fish scales from five Mediterranean fish species and Atlantic salmon, it was found that fish scales could be efficiently utilized for the production of high added-value biomaterials. The isolated collagenous materials showed typical electrophoretic patterns of type I collagen, and were morphologically and physicochemically characterized for potential applications in the biomedical sector.
In search of alternative and sustainable sources of collagenous materials for biomedical applications, the scales of five Mediterranean fish species-fished in high tonnage in the Mediterranean region since they represent popular choices for the local diet-as well as those of the Atlantic salmon for comparison purposes, were comparatively studied for their acid- and pepsin-soluble collagen content. Fish scales that currently represent a discarded biomass of no value could be efficiently exploited for the production of a high added-value biomaterial. The isolated collagenous materials, which showed the typical electrophoretic patterns of type I collagen, were morphologically and physicochemically characterized. Using scanning electron microscopy the fibrous morphology of the isolated collagens was confirmed, while the hydroxyproline content, in conjunction with infrared spectroscopy and X-ray diffraction studies verified the characteristic for collagen amino acid profile and its secondary structure. The acid- and pepsin-soluble collagens isolated from the fish scales were blended with the bioactive sulfated marine polysaccharide ulvan and polyethylene oxide and electrospun to afford nanofibrous scaffolds that could find applications in the biomedical sector.
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