4.7 Article

Supramolecular Coassembled Peptide Hydrogels for Efficient Anticancer Therapy by RNS-Based PDT and Immune Microenvironment Regulation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Biomedical

Antigen epitope-TLR7/8a conjugate as self-assembled carrier-free nanovaccine for personalized immunotherapy

Huijuan Song et al.

Summary: An epitope-based vaccine platform has been developed, which self-assembles into nanostructures without the use of additional carriers. It effectively introduces antigen and adjuvant, enhances dendritic cell activation and T-cell immunity, and shows potential therapeutic effects.

ACTA BIOMATERIALIA (2022)

Article Chemistry, Multidisciplinary

Codelivery of Shikonin and siTGF-β for enhanced triple negative breast cancer chemo-immunotherapy

Ji Li et al.

Summary: By constructing an effective codelivery system combining tumor growth factor beta (TGF-beta) small interference RNA (siTGF-beta) and shikonin (SK), this study achieved successful chemoimmunotherapy of triple-negative breast cancer (TNBC), inhibiting tumor growth and metastasis while generating long-term immunological memory response.

JOURNAL OF CONTROLLED RELEASE (2022)

Review Medicine, Research & Experimental

Targeting regulated cell death in tumor nanomedicines

Qinghu Zeng et al.

Summary: Nanomedicines have great potential in anticancer therapy, but they are limited by self-protection mechanisms and treatment resistance of cancer cells. Recent studies have shown that regulating cell death can enhance the therapeutic efficiency of tumors. This article introduces various strategies of regulated cell death-mediated synergistic tumor nanotherapeutics and discusses the coordination mechanisms.

THERANOSTICS (2022)

Article Engineering, Biomedical

Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance

Yumin Zhang et al.

Summary: This study aimed to overcome radioresistance in tumors by regulating the polarization of tumor-associated macrophages (TAMs) using a toll-like receptor agonist TLR7/8a conjugated with a radiosensitive peptide hydrogel (Smac-TLR7/8 hydrogel). The results showed that the Smac-TLR7/8 hydrogel effectively polarized TAMs into an anti-tumor M1 phenotype upon gamma-ray radiation. The repolarization of TAMs promoted tumor necrosis factor secretion, activated the anti-tumor immune response, and inhibited tumor growth. Furthermore, TAMs repolarization enhanced the efficacy of PD1-blockade by increasing tumor infiltrating lymphocytes (TILs) and decreasing Treg cells in solid tumors.

BIOACTIVE MATERIALS (2022)

Review Engineering, Biomedical

Free radicals for cancer theranostics

Xiao-Qiang Wang et al.

Summary: Free radicals, traditionally seen as harmful, can also have beneficial applications in health due to their unique electronic structure. Their properties like high reactivity and conversion ability make them attractive for biomedical applications.

BIOMATERIALS (2021)

Article Engineering, Biomedical

Polymer-lipid hybrid nanovesicle-enabled combination of immunogenic chemotherapy and RNAi-mediated PD-L1 knockdown elicits antitumor immunity against melanoma

Changrong Wang et al.

Summary: The combination of RNA interference and immunogenic chemotherapy shows potent antitumor immunity against melanoma. Using cationic polymer-lipid hybrid nanovesicles as a delivery system, the strategy induces immunogenic cell death and enhances antitumor immune responses effectively.

BIOMATERIALS (2021)

Article Engineering, Biomedical

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Boyi Niu et al.

Summary: Glutathione (GSH) plays a crucial role in cellular antioxidative system, particularly in cancer cells, where a high level of GSH is essential for scavenging ROS and detoxifying xenobiotics. Depletion of GSH has been shown to enhance the efficacy of various therapies such as ROS-based therapy, ferroptosis, and chemotherapy. This review comprehensively discusses the importance of GSH depletion in cancer therapy and various strategies employed to achieve it.

BIOMATERIALS (2021)

Review Oncology

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Razan Alzeibak et al.

Summary: The past decade has seen significant breakthroughs in cancer immunotherapy, with immunogenic cell death (ICD) emerging as a promising approach to eliminate tumor cells. Photodynamic therapy (PDT) can induce ICD, but its efficiency is reduced in hypoxic tumor environments. Future research may focus on strategies like oxygen-boosted PDT and nanotechnology to address this limitation.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Cell Biology

Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

Mikhail Binnewies et al.

Summary: Research has identified a correlation between TREM2(+) tumor-associated macrophages (TAMs) and exhausted CD8(+) tumor-infiltrating lymphocytes (TILs), with therapy targeting TREM2 showing potential in promoting anti-tumor immunity.

CELL REPORTS (2021)

Article Chemistry, Multidisciplinary

Microenvironment-Responsive Prodrug-Induced Pyroptosis Boosts Cancer Immunotherapy

Yao Xiao et al.

Summary: The absence of tumor antigens poses a challenge in ICB therapy, but inducing tumor-specific pyroptosis while reducing injury in normal tissues is urgently needed. A ROS/GSH dual-responsive nano-prodrug called MCPP with high PTX and P18 loading is designed to selectively induce pyroptosis in tumor cells. Chemo-photodynamic therapy and controlled-release PTX synergistically induce pyroptosis, releasing DAMPs and enhancing ICB efficiency, suggesting a smart strategy to trigger pyroptosis and augment ICB efficiency.

ADVANCED SCIENCE (2021)

Article Engineering, Biomedical

Ruthenium(II) complexes coordinated to graphitic carbon nitride: Oxygen self-sufficient photosensitizers which produce multiple ROS for photodynamic therapy in hypoxia

Fangmian Wei et al.

Summary: The novel oxygen self-sufficient photosensitizer Ru-g-C3N4, designed to overcome tumor hypoxia-induced resistance in photodynamic therapy, shows enhanced water solubility, visible light absorption, and biocompatibility. Through catalyzing decomposition of H2O2 and H2O to generate O2, Ru-g-C3N4 significantly improves PDT efficacy by producing multiple reactive oxygen species and alleviating tumor hypoxia. This metal complex-grafted g-C3N4 photosensitizer represents a groundbreaking development in oxygen-producing photodynamic therapy agents.

BIOMATERIALS (2021)

Article Chemistry, Physical

Engineering of a dual-modal phototherapeutic nanoplatform for single NIR laser-triggered tumor therapy

Mengzhu Zhang et al.

Summary: This study introduces a novel dual-modal phototherapeutic nanoplatform that achieves both PDT and PTT under single 660 nm laser irradiation by integrating core-shell structured CuS@Carbon with Ce6.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Article Chemistry, Multidisciplinary

Charge-switchable nanoparticles enhance Cancer immunotherapy based on mitochondrial dynamic regulation and immunogenic cell death induction

Ming Zhao et al.

Summary: The development of twin-like charge-switchable nanoparticles provides a selective delivery system for targeting tumor-associated macrophages and cancer cells, reversing the immunosuppressive tumor microenvironment and enhancing the effectiveness of cancer immunotherapy.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Multidisciplinary

Switching Reactive Oxygen Species into Reactive Nitrogen Species by Photocleaved O2-Released Nanoplatforms Favors Hypoxic Tumor Repression

Tao Luo et al.

Summary: A photocleaved O-2-released nanoplatform is developed to convert ROS into RNS for long-lasting antitumor effects, by continuously releasing oxygen and alleviating hypoxia to elevate ROS levels.

ADVANCED SCIENCE (2021)

Review Engineering, Biomedical

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

Muyue Yang et al.

Summary: The development and metastasis of tumors are closely linked to the tumor microenvironment (TME). Nanoparticles, with their unique physical properties and design, show potential in efficiently penetrating TME and delivering therapeutic agents to specific components. However, the heterogeneity of tumors and individuals may limit the effectiveness of nanoparticle delivery systems in all types of tumors, calling for further understanding of TME changes at different stages of tumor development for the design of more personalized nanoplatforms.

BIOACTIVE MATERIALS (2021)

Article Chemistry, Multidisciplinary

A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

Jing Zhang et al.

Summary: The study proposed a two-pronged concept combining photodynamic therapy and epithelial-mesenchymal transition blockade to combat basal-like breast cancer metastasis. Ce6/Epa nanoparticles effectively prevented BLBC metastasis in vivo, offering a promising dual strategy against BLBC metastasis.

CHEMICAL COMMUNICATIONS (2021)

Article Immunology

Redox regulation of immunometabolism

Jonathan Muri et al.

Summary: Immunometabolism research has revealed the significant impact of metabolic pathways and redox systems on immune cell functions, including the role of reactive oxygen species (ROS) and antioxidant pathways like thioredoxin and glutathione pathways. Studies show the central role of metabolism in determining the fate and function of immune cells, with cellular activation inducing profound changes in their oxidation-reduction system.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Innate-adaptive immunity interplay and redox regulation in immune response

Lizhe Sun et al.

REDOX BIOLOGY (2020)

Article Multidisciplinary Sciences

Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment

Yingxia Zheng et al.

NATURE COMMUNICATIONS (2020)

Review Chemistry, Multidisciplinary

Forster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents

Luling Wu et al.

CHEMICAL SOCIETY REVIEWS (2020)

Review Cell Biology

Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale et al.

CELL METABOLISM (2019)

Review Chemistry, Multidisciplinary

Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy

Guo-Bin Qi et al.

ADVANCED MATERIALS (2018)

Review Biochemistry & Molecular Biology

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents

Matteo Santoni et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)

Review Chemistry, Multidisciplinary

Supramolecular photosensitizers rejuvenate photodynamic therapy

Xingshu Li et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Engineering, Biomedical

ROS-induced NO generation for gas therapy and sensitizing photodynamic therapy of tumor

Shuang-Shuang Wan et al.

BIOMATERIALS (2018)

Article Chemistry, Multidisciplinary

Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy

Sara Musetti et al.

ACS NANO (2018)

Article Chemistry, Multidisciplinary

Glucose-Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving-Like/Gas Therapy

Wenpei Fan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Biochemistry & Molecular Biology

Polysaccharides from ginseng leaves inhibit tumor metastasis via macrophage and NK cell activation

Myoung-Sook Shin et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

Review Oncology

Tumour-associated macrophages as treatment targets in oncology

Alberto Mantovani et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Review Pharmacology & Pharmacy

Progress in tumor-associated macrophage (TAM)-targeted therapeutics

Chayanon Ngambenjawong et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Article Nanoscience & Nanotechnology

Targeted Chemo-Photodynamic Combination Platform Based on the DOX Prodrug Nanoparticles for Enhanced Cancer Therapy

Yumin Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Multidisciplinary Sciences

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Olivier De Henau et al.

NATURE (2016)

Review Oncology

Vaccines for established cancer: overcoming the challenges posed by immune evasion

Sjoerd H. van der Burg et al.

NATURE REVIEWS CANCER (2016)

Editorial Material Medicine, Research & Experimental

Cancer immunotherapy: harnessing the immune system to battle cancer

Yiping Yang

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Biochemistry & Molecular Biology

Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction

Adelheid Weidinger et al.

BIOMOLECULES (2015)

Review Immunology

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Biotechnology & Applied Microbiology

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

Csaba Szabo et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Article Biochemical Research Methods

Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences

Irene Coin et al.

NATURE PROTOCOLS (2007)