期刊
LWT-FOOD SCIENCE AND TECHNOLOGY
卷 167, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.lwt.2022.113817
关键词
Exopolysaccharide; Anticancer; Antidiabetic; ACE-Inhibition; Antioxidants
资金
- Jordan University of Science and Technology
- United Arab Emirates University
This study investigates and characterizes the bioactivities of two novel exopolysaccharides, EPS-S and EPS-L, and reveals their potential applications in the food and nutraceutical industries, as they exhibit anticancer, antimicrobial, and enzyme inhibitory activities.
This study aimed to investigate and characterize the bioactivities of two novel exopolysaccharides, EPS-S and EPS-L, produced respectively by Streptococcus thermophilus and Lactobacillus bulgaricus that were newly isolated from labaneh. Both EPSs are composed of glucose and other sugars, with average molecular weights of 537.80 kDa and 248.15 kDa, ZP of-26.7 and-44.83 mV, and particle sizes of 824.5 and 757.9 nm IC(50 )values of EPS-S and EPS-L against colon cancer cells (HT-29, HCT-116) were 5.01 and 0.79 mg/mL and 4.20 and 3.46 mg/mL, respectively. Both EPSs displayed a bactericidal effect against Listeria monocytogenes , while EPS-L exhibited significant inhibition of methicillin-resistant Staphylococcus aureus. EPS-S inhibited 53.8% of alpha-amylase, 9.2% of alpha-glucosidase, and 25.9% of angiotensin-converting enzyme (ACE), while EPS-L inhibited 47.8% of alpha-amylase, 11.9% of alpha-glucosidase, and 52.5% of ACE. This study reveals promising biological properties of EPS-S and EPS-L for potential applications in the food and nutraceutical industries.
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