期刊
LUNG CANCER
卷 173, 期 -, 页码 21-27出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2022.08.022
关键词
Lung cancer; Neighborhood socioeconomic status; Disadvantage; Health disparities; PM2.5 exposure
资金
- City of Hope Paul Calabresi Career Development Award for Clinical Oncology [K12 CA001727]
- National Institutes of Health [CA058420, CA164974]
- Karin Grunebaum Cancer Research Foundation
Living in neighborhoods with concentrated disadvantage may increase the risk of lung cancer in Black women who have never smoked. Understanding and targeting non-tobacco-related factors in disadvantaged neighborhoods could help achieve health equity.
Background: Compared to women of other races who have never smoked, Black women have a higher risk of lung cancer. Whether neighborhood disadvantage, which Black women experience at higher rates than other women, is linked to never-smoking lung cancer risk remains unclear. This study investigates the association of neighborhood disadvantage and lung cancer risk in Black never-smoking women. Methods and materials: This research utilized data from the Black Women's Health Study, a prospective cohort of 59,000 Black women recruited from across the US in 1995 and followed by biennial questionnaires. Associations of lung cancer incidence with neighborhood-level factors (including two composite variables derived from Census Bureau data: neighborhood socioeconomic status and neighborhood concentrated disadvantage), secondhand smoke exposure, and PM2.5 were estimated using Fine-Gray subdistribution hazard models. Results: Among 37,650 never-smokers, 77 were diagnosed with lung cancer during follow-up from 1995 to 2018. The adjusted subdistribution hazard ratio (sHR) of lung cancer incidence with ten unit increase in neighborhood concentrated disadvantage index was 1.30 (95 % CI: 1.04, 1.63, p = 0.023). Exposure to secondhand smoke at work was associated with increased risk (sHR = 1.93, 95 % CI: 1.21, 3.10, p = 0.006), but exposure to secondhand smoke at home and PM2.5 was not. Conclusion: Worse neighborhood concentrated disadvantage was associated with increased lung cancer risk in Black women who never smoked. These findings suggest that non-tobacco-related factors in disadvantaged neighborhoods may be linked to lung cancer risk in Black women and that these factors must be understood and targeted to achieve health equity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据