Growth regulated oncogene-? contribute to EMT/MMPs pathway by binding its receptors in head and neck squamous cell carcinoma

Review Biochemistry & Molecular Biology

Colorectal liver metastasis: molecular mechanism and interventional therapy

Hui Zhou et al.

Summary: This review summarizes the mechanisms, diagnosis, and treatment of colorectal liver metastasis (CRLM), with a special focus on the tumor microenvironment and the potential of newer targeted therapies to improve patient prognosis.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Oncology

The Epithelial-Mesenchymal Transition Influences the Resistance of Oral Squamous Cell Carcinoma to Monoclonal Antibodies via Its Effect on Energy Homeostasis and the Tumor Microenvironment

Yunpeng Bai et al.

Summary: The resistance to monoclonal antibodies (mAbs) in treating oral squamous cell carcinoma (OSCC) is a major challenge in management. Epithelial-mesenchymal transition (EMT) plays a crucial role in the development of mAbs resistance and shaping the tumor microenvironment, impacting immune evasion. Focusing on the energy balance between cancer cells and T-cells could offer a new perspective for treating OSCC.

CANCERS (2021)

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Article Oncology

A Role of CXCL1 Drives Osteosarcoma Lung Metastasis via VCAM-1 Production

Chiang-Wen Lee et al.

Summary: CXCL1 and CXCR2 play crucial roles in lung metastasis of osteosarcoma by promoting neutrophil infiltration into the tumor microenvironment, affecting cell migration and invasion activities. Additionally, CXCL1 activates the CXCR2/FAK/PI3K/Akt signaling pathway to promote the expression and nuclear translocation of VCAM-1, thus playing a critical role in osteosarcoma metastasis to the lung.

FRONTIERS IN ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology

The functional GRHL3-filaggrin axis maintains a tumor differentiation potential and influences drug sensitivity

Yuchen Bai et al.

Summary: This study reveals the existence of a functional GRHL3-FLG differentiation axis in head and neck squamous cell carcinoma, which can regulate targeted therapy response. Patients are stratified into treatment resistant or sensitive subsets based on the mutational profile of the FLG gene.

MOLECULAR THERAPY (2021)

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Review Medicine, General & Internal

The Role of Chemokines in Cervical Cancers

Fabian Garrido et al.

Summary: Chemokines play a key role in activating immune checkpoints in cervical cancer progression, affecting prognosis in various aspects. Understanding chemokines and immune checkpoint modulators is crucial for effective treatment of the disease.

MEDICINA-LITHUANIA (2021)

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Review Pharmacology & Pharmacy