4.3 Article

A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

期刊

LEUKEMIA & LYMPHOMA
卷 63, 期 14, 页码 3351-3361

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2022.2131419

关键词

Red blood cell membrane fatty acids; polyunsaturated fatty acids; non-Hodgkin lymphoma; epidemiology; prospective; etiology

资金

  1. American Cancer Society [RSG-11-020-01-CNE]
  2. National Institutes of Health [UM1 CA186107, P01 CA87969, R01 CA49449, U01 CA167552, R01 CA149445, R01 CA09812, U54 CA155626, P30 DK46200, KL2 TR001455, T32 CA009001]
  3. American Heart Association [834106]

向作者/读者索取更多资源

Published studies on the association between polyunsaturated fatty acid (PUFA) intake and non-Hodgkin lymphoma (NHL) risk have yielded inconsistent results. This nested case-control study, involving participants from the Nurses' Health Study and Health Professionals Follow-Up Study, found no overall association between red blood cell (RBC) membrane PUFA levels and NHL risk. However, certain PUFA were associated with specific types of lymphoma, and the reasons for these unexpected associations remain unclear.
Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses' Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03-1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23-4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.

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