期刊
LEUKEMIA & LYMPHOMA
卷 63, 期 14, 页码 3456-3461出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2022.2123227
关键词
Primary myelofibrosis; second primary malignancy; incidence; leukemia; melanoma
This study used a database to assess the risk of second primary malignancy (SPM) in patients with primary myelofibrosis (PMF). The findings indicate a higher risk of SPM in PMF patients and identify associated risk factors such as age, gender, treatment, and time of diagnosis.
Prior studies report a greater incidence of second primary malignancy (SPM) among patients with myeloproliferative neoplasms, although the true risk in primary myelofibrosis (PMF) has not been elucidated. We utilized the Surveillance, Epidemiology, and End Results database to evaluate the risk of SPM in PMF patients and analyzed the effects of sociodemographic factors on the risk of SPM. Out of 5273 patients, 385 patients (7.30%) developed SPM. SPM occurred at SIR of 1.95 (95% CI 1.76-2.15) and AER of 149.01 per 10,000 population. A significantly higher incidence of melanoma (SIR 1.76, 95% CI 1.01-2.86), lymphoma (SIR 3.38, 95% CI 2.28-4.83), and leukemia (SIR 27.19, 95% CI 23.09-31.81) was observed. The risk was significantly higher in patients <= 60 years, males, chemotherapy recipients, within 5 years of PMF diagnosis, and for PMF diagnosed after 2009.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据