4.7 Letter

Impact of emerging ACA on survival in chronic myeloid leukemia (CML)

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Additional chromosomal abnormalities at chronic myeloid leukemia diagnosis predict an increased risk of progression

Richard E. Clark et al.

Summary: In patients with chronic-phase CML, the presence of additional cytogenetic abnormalities (ACAs) beyond the standard Philadelphia translocation is associated with a higher risk of disease progression, leading to poorer progression-free survival (PFS) and freedom from progression (FFP). The study found that certain ACAs are predictive of disease progression independent of traditional risk scores like Sokal or ELTS.

BLOOD ADVANCES (2021)

Article Multidisciplinary Sciences

Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia

Yotaro Ochi et al.

Summary: In chronic myeloid leukaemia (CML), the drivers of blast crisis and resistance to tyrosine kinase inhibitors are not fully characterised. Analysis of a cohort of CML samples using genomic technologies reveals that at least one driver alteration is associated with progression and worse prognosis. Genetic abnormalities can help predict clinical outcomes and guide clinical decisions in CML.

NATURE COMMUNICATIONS (2021)

Review Hematology

Chronic Myeloid Leukemia in 2020

Ruediger Hehlmann

HEMASPHERE (2020)

Review Hematology

Cytogenetic and molecular genetic evolution of chronic myeloid leukemia

B Johansson et al.

ACTA HAEMATOLOGICA (2002)