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Influenza

LANCET (2022)

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Characteristics and Outcomes of Hospitalized Pregnant Women With Influenza, 2010 to 2019 A Repeated Cross-Sectional Study

Rachel Holstein et al.

Summary: The study found that one third of reproductive-aged women hospitalized with influenza were pregnant over the course of 9 influenza seasons. Pregnant women with influenza A H1N1 had more severe outcomes. It is recommended that pregnant women remain a high-priority target group for vaccination.

ANNALS OF INTERNAL MEDICINE (2022)

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Article Infectious Diseases

Bacterial co-infections in community-acquired pneumonia caused by SARS-CoV-2, influenza virus and respiratory syncytial virus

Pontus Hedberg et al.

Summary: A lower prevalence of bacterial co-infections was observed in patients with community-acquired SARS-CoV-2 positive pneumonia compared to those with influenza and RSV positive pneumonia.

BMC INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Combining baloxavir marboxil with standard-of-care neuraminidase inhibitor in patients hospitalised with severe influenza (FLAGSTONE): a randomised, parallel-group, double-blind, placebo-controlled, superiority trial

Deepali Kumar et al.

Summary: This study tested the combination of baloxavir with NAIs in hospitalized patients with severe influenza but found no superior clinical outcomes compared to NAIs alone. The combination was well tolerated, suggesting that combination antivirals may not be routinely indicated in clinical practice for this patient population.

LANCET INFECTIOUS DISEASES (2022)

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Article Environmental Sciences

Influenza seasonality and its environmental driving factors in mainland China and Hong Kong

Sheikh Taslim Ali et al.

Summary: The study found that absolute humidity is a key factor influencing the seasonality of influenza, showing a U-shaped association with transmissibility and able to predict the transmission patterns of influenza virus in different climate zones. Other climatic factors and holiday-related school closures also have a certain impact on influenza transmission.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Immunology

Epidemiology, Clinical Characteristics, and Outcomes of Influenza-Associated Hospitalizations in US Children Over 9 Seasons Following the 2009 H1N1 Pandemic

Satoshi Kamidani et al.

Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Influenza returns with a season dominated by clade 3C.2a1b.2a.2 A(H3N2) viruses, WHO European Region, 2021/22

Angeliki Melidou et al.

Summary: Non-pharmaceutical interventions for COVID-19 have continued to slow down the circulation of influenza in the WHO European Region in the 2021/22 season. The A(H-3) virus strain has dominated, co-circulating with A(H-1)pdmo9 and B/Victoria viruses in some countries. No detections of the B/Yamagata virus have been confirmed. Many of the circulating virus subtypes or lineages have shown antigenic differences from their respective vaccine components in the northern hemisphere. Adequate levels of influenza virus characterizations should be maintained until the end of the season and in future seasons, when surveillance is adapted to include SARS-CoV-2.

EUROSURVEILLANCE (2022)

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Article Infectious Diseases

Comparison of the safety and immunogenicity of a novel Matrix-M-adjuvanted nanoparticle influenza vaccine with a quadrivalent seasonal influenza vaccine in older adults: a phase 3 randomised controlled trial

Vivek Shinde et al.

Summary: The study aimed to compare the immunological responses of the Matrix-M-adjuvanted quadrivalent nanoparticle influenza vaccine (qNIV) with a licensed, standard-dose quadrivalent inactivated influenza vaccine (IIV4) in older adults. The results showed that qNIV was immunologically non-inferior to IIV4, well tolerated, and produced enhanced immune responses in older adults, indicating potential effectiveness in seasonal influenza vaccination.

LANCET INFECTIOUS DISEASES (2022)

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Article Medicine, Research & Experimental

Bat-Borne Influenza A Viruses: An Awakening

Kevin Ciminski et al.

Summary: Influenza A viruses from aquatic waterfowl recurrently cross interspecies barriers by utilizing cell surface-exposed monosaccharide sialic acids as a universal host cell receptor. Batborne IAV subtypes H17N10 and H18N11 encode HA and NA homologs unable to interact with sialic acid residues, but instead use major histocompatibility complex class II proteins of different vertebrate species for cell entry, potentially allowing for a broader host tropism.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2021)

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Article Medicine, Research & Experimental

Original Antigenic Sin: How Original? How Sinful?

Jonathan W. Yewdell et al.

Summary: Original antigenic sin (OAS) is a phenomenon in antibody responses to influenza A virus infection or vaccination, which depends on multiple variables. It is not a sin, but rather a part of evolutionary selection that can help improve influenza virus vaccines.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2021)

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Article Medicine, Research & Experimental

Influenza Therapeutics in Clinical Practice-Challenges and Recent Advances

John H. Beigel et al.

Summary: This article summarizes recent clinical developments involving influenza antiviral drugs in various categories and important clinical research issues, many of which have knowledge gaps due to unpublished data and ongoing pivotal studies.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2021)

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Article Medicine, General & Internal

Dexamethasone in Hospitalized Patients with Covid-19

Peter Horby et al.

Summary: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Public, Environmental & Occupational Health

Racial/Ethnic and Socioeconomic Disparities in Adult Vaccination Coverage

Kosuke Kawai et al.

Summary: Racial and ethnic disparities in vaccine uptake persisted over the last decade, while socioeconomic disparities narrowed among adults aged 18-64 years but persisted among adults aged >= 65 years.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2021)

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Article Immunology

Waning Vaccine Effectiveness Against Influenza-Associated Hospitalizations Among Adults, 2015-2016 to 2018-2019, United States Hospitalized Adult Influenza Vaccine Effectiveness Network

Jill M. Ferdinands et al.

Summary: The effectiveness of influenza vaccine decreases with time since vaccination, with an absolute decline of about 8%-9% per month postvaccination.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Global production capacity of seasonal and pandemic influenza vaccines in 2019

Erin Sparrow et al.

Summary: The study compares global capacity for production of influenza vaccines in 2019, showing a slight increase in annual seasonal influenza vaccine production capacity and a rising trend in potential annual influenza pandemic vaccine production capacity. However, these estimates should be interpreted cautiously as they are based on assumptions that may impact supply. Pandemic vaccines would not be immediately available, taking four to six months for initial supplies with further time needed to reach maximum capacity.

VACCINE (2021)

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Review Immunology

Variable seasonal influenza vaccine effectiveness across geographical regions, age groups and levels of vaccine antigenic similarity with circulating virus strains: A systematic review and meta-analysis of the evidence from test-negative design studies after the 2009/10 influenza pandemic

G. N. Okoli et al.

Summary: The study found consistent patterns in seasonal influenza vaccine effectiveness across different regions, age groups, and levels of vaccine antigenic similarity with circulating virus strains. The highest vaccine performance was against A(H1N1)pdm09, while the worst was against A(H3N2). Geographic location, age, and vaccine antigenic similarity with circulating virus strains should be considered when designing and evaluating influenza vaccine effectiveness studies.

VACCINE (2021)

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Editorial Material Surgery

What Is an Aerosol-Generating Procedure?

Michael Klompas et al.

JAMA SURGERY (2021)

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Letter Infectious Diseases

Re-emergence of influenza virus circulation during 2020 in parts of tropical Asia: Implications for other countries

Joshua A. Mott et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2021)

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News Item Biotechnology & Applied Microbiology

mRNA flu shots move into trials

Elie Dolgin

Summary: The COVID-19 pandemic demonstrated the effectiveness of mRNA vaccines and now pharmaceutical companies are racing to apply this technology platform to influenza vaccines.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Medicine, General & Internal

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Anthony C. Gordon et al.

Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis

Kathryn E. Lafond et al.

Summary: This study aimed to estimate the global burden of influenza-associated hospitalizations among adults worldwide. The researchers conducted a systematic review and meta-analysis, finding that influenza was associated with 14% of acute respiratory hospitalizations in adults, with over 5 million cases annually. The findings emphasize the importance of influenza vaccination, especially for older adults, in preventing severe disease and hospitalizations.

PLOS MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

Effects of Influenza Vaccine on Mortality and Cardiovascular Outcomes in Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis

Siva H. Yedlapati et al.

Summary: The study found that influenza vaccination in patients with cardiovascular disease is associated with a lower risk of all-cause mortality, cardiovascular mortality, and major adverse cardiovascular events. However, it did not show a significant reduction in the risk of myocardial infarction compared to the control group.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Infectious Diseases

Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients

Jiazhen Zheng et al.

Summary: The study revealed that co-infection of H1N1 and SARS-CoV-2 leads to more severe complications, heavier clinical symptoms, and requires more urgent medical interventions compared to mono-infections. Additionally, initial Ct values can provide important clues for the progression of the co-infection.

PLOS NEGLECTED TROPICAL DISEASES (2021)

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Review Immunology

Effectiveness of Influenza Vaccination in Preventing Hospitalization Due to Influenza in Children: A Systematic Review and Meta-analysis

Nicki L. Boddington et al.

Summary: This systematic review found that the effectiveness of influenza vaccine against hospitalization in children varies by influenza subtype and vaccine type, with an overall seasonal IVE of 53.3%. IVE was highest against influenza A/H1N1pdm09 and lowest against influenza A/H3N2.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Effectiveness of Influenza Vaccines in the HIVE Household Cohort Over 8 Years: Is There Evidence of Indirect Protection?

Ryan E. Malosh et al.

Summary: This study found that the direct effect of influenza vaccine in the HIVE cohort was higher for A/H1N1 and B influenza, and young children had higher direct vaccine effectiveness than adults. Influenza incidence was highest in completely unvaccinated households, and lower in households with vaccination coverage. The study suggests that while influenza vaccines may have benefits beyond direct protection, the indirect effect is small.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Infectious Diseases

A remote household-based approach to influenza self-testing and antiviral treatment

Jessica Heimonen et al.

Summary: Through at-home testing, telehealth care, and rapid antiviral home delivery, we demonstrated the feasibility of self-testing combined with rapid home delivery of influenza antiviral treatment, which may be an important control strategy for influenza epidemics and pandemics.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2021)

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Article Public, Environmental & Occupational Health

Interactions between SARS-CoV-2 and influenza, and the impact of coinfection on disease severity: a test-negative design

Julia Stowe et al.

Summary: The study found that influenza patients had a lower risk of SARS-CoV-2 infection, but those with coinfections had a higher risk of death, especially in terms of ventilator use and intensive care unit admission.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2021)

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Review Microbiology

Transmissibility and transmission of respiratory viruses

Nancy H. L. Leung

Summary: Respiratory virus infections cause a significant global health problem, with different viruses varying in transmission modes and transmissibility. Understanding the relative contributions of different transmission modes is crucial for guiding the effectiveness of non-pharmaceutical interventions.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Pharmacology & Pharmacy

Neuraminidase inhibitors and single dose baloxavir are effective and safe in uncomplicated influenza: a meta-analysis of randomized controlled trials.

Sofia Tejada et al.

Summary: The study found that baloxavir and neuraminidase inhibitors (NAIs) have a significant reduction effect on complications of uncomplicated influenza, especially in reducing antibiotic prescriptions. Single-dose baloxavir is non-inferior to NAIs in terms of safety and efficacy.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2021)

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Editorial Material Critical Care Medicine

Aerosol generating procedures: are they of relevance for transmission of SARS-CoV-2?

Fergus Hamilton et al.

LANCET RESPIRATORY MEDICINE (2021)

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Review Immunology

Clinical Effectiveness and Safety of Antivirals for Influenza in Pregnancy

Eric J. Chow et al.

Summary: Early initiation of antiviral treatment of influenza is beneficial in reducing the risk of complications and duration of illness. Pregnant and postpartum women treated with oseltamivir and other neuraminidase inhibitors show reduced risk of severe outcomes with no increase in adverse maternal, fetal, or neonatal outcomes. Baloxavir is not recommended for use in these populations due to lack of safety and efficacy data.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Critical Care Medicine

Early Bacterial Identification among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Clinical Trial

Anahita Rouze et al.

Summary: The prevalence of bacterial identification within 48 hours after intubation is significantly lower in patients with SARSCoV-2 pneumonia compared to influenza pneumonia. Bacterial identification is associated with increased 28-day mortality in patients with SARS-CoV-2 pneumonia.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Medicine, General & Internal

Association Between Caseload Surge and COVID-19 Survival in 558 US Hospitals, March to August 2020

Sameer S. Kadri et al.

Summary: A retrospective cohort study conducted on COVID-19 patients from 558 U.S. hospitals between March and August 2020 found a significant increase in COVID-19 mortality rate with higher surge index percentiles, with the highest mortality rate observed in the 99th percentile and above. The study also revealed that despite increased use of corticosteroids and more judicious intubation in later months, the surge-mortality relationship was stronger in June to August compared to March to May.

ANNALS OF INTERNAL MEDICINE (2021)

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Review Biochemistry & Molecular Biology

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

Gerwyn Morris et al.

Summary: An analysis of cytokine storms in diseases like COVID-19, H1N1 influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) reveals common immunological and biochemical abnormalities. These include hyperactive coagulation systems, elevated levels of cytokines, proinflammatory chemokines, and activated macrophages. Differences in immune responses and cytokine levels are also observed among these diseases. Additional elements such as Inflammasome activity and DAMPs contribute to the pathophysiology of cytokine storms.

CYTOKINE (2021)

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Article Immunology

Comprehensive Immunologic Evaluation of Bronchoalveolar Lavage Samples from Human Patients with Moderate and Severe Seasonal Influenza and Severe COVID-19

Daniel Reynolds et al.

Summary: Severe cases of seasonal influenza or SARS-CoV-2 infection are associated with an influx of nonclassical monocytes, activated T cells, and plasmablast B cells into the lower airways, along with significantly elevated levels of 28 out of 35 measured cytokines. IP-10 concentration is the only cytokine that correlates between blood and bronchoalveolar lavage during severe infection.

JOURNAL OF IMMUNOLOGY (2021)

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Article Immunology

Viral RNA and Infectious Influenza Virus on Mobile Phones of Patients With Influenza in Hong Kong and the United States

Jingyi Xiao et al.

Summary: The research found that the presence of influenza viral RNA on mobile phones is positively correlated with the upper respiratory tract viral load of patients and negatively correlated with the age of the patients.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Immunology

Quantifying the Impact of COVID-19 Nonpharmaceutical Interventions on Influenza Transmission in the United States

Yuchen Qi et al.

Summary: The study found that NPIs implemented in 2020 had significant effects on reducing the incidence and transmission of seasonal influenza in the United States, with more than 60% reduction in certain influenza strains during the initial 10 weeks. The reduction in influenza transmission varied geographically, and the potential accumulation of susceptibility to influenza infection post-NPIs may lead to large outbreaks, whose scale could be impacted by the duration of intervention and immunity to influenza. Healthcare systems should prepare for potential surges in influenza patients and promote vaccination and ongoing precautions.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Immunology

A case series of parainfectious Guillain-Barre syndrome linked to influenza A (H1N1) virus infection

Stefano Giuseppe Grisanti et al.

Summary: GBS is an immune-mediated peripheral neuropathy characterized by a typical post-infectious profile. Some cases have been reported to occur shortly after Zika virus or severe acute respiratory syndrome-related coronavirus-2 infections. In some cases, patients with a history of influenza A (H1N1) virus infection developed GBS in a very short period of time, with some recovering promptly without therapy. The parainfectious cases add heterogeneity to the GBS category, warranting further pathogenetic insights.

JOURNAL OF NEUROIMMUNOLOGY (2021)

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Article Pediatrics

Influenza-Associated Neurologic Complications in Hospitalized Children

Sarah Frankl et al.

Summary: This study found that influenza-associated neurologic complications are common in children hospitalized with influenza. Seizures and encephalopathy were the most commonly identified complications, and children with pre-existing neurologic diagnoses had a higher proportion of these complications. The study suggests that vaccination, lack of seasonal influenza vaccination, and age <= 5 years are independently associated with influenza-associated neurologic complications.

JOURNAL OF PEDIATRICS (2021)

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Article Obstetrics & Gynecology

Influenza Complicating Delivery Hospitalization and Its Association With Severe Maternal Morbidity in the United States, 2000-2018

Timothy Wen et al.

Summary: The study found that an influenza diagnosis at delivery hospitalization is associated with an increased risk of severe maternal morbidity, including maternal death, mechanical intubation, sepsis, shock, acute respiratory distress syndrome, and obstetric complications. The results underscore the importance of primary prevention and early detection of influenza during pregnancy to reduce maternal morbidity and mortality.

OBSTETRICS AND GYNECOLOGY (2021)

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Article Pediatrics

Influenza Antiviral Treatment and Length of Stay

Angela P. Campbell et al.

Summary: This study evaluated the impact of antiviral treatment on hospital length of stay among children hospitalized with confirmed influenza, finding that early antiviral treatment was associated with significantly shorter hospitalizations. These results support the CDC recommendations for prompt empiric antiviral treatment in hospitalized patients with suspected or confirmed influenza.

PEDIATRICS (2021)

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Review Immunology

Does influenza vaccination attenuate the severity of breakthrough infections? A narrative review and recommendations for further research

Jill M. Ferdinands et al.

Summary: Influenza vaccination is associated with reduced odds of ICU admission and death among adults with influenza-associated hospitalization, as well as reduced odds of fever among children with influenza virus infection.

VACCINE (2021)

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Article Multidisciplinary Sciences

Impact of COVID-19 outbreaks and interventions on influenza in China and the United States

Luzhao Feng et al.

Summary: Research suggests that COVID-19 outbreaks and related NPIs may have significantly reduced influenza activity in China and the United States during the 2019-2020 season, indicating a potential impact of NPIs on the spread of infectious diseases.

NATURE COMMUNICATIONS (2021)

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Asymptomatic transmission and high community burden of seasonal influenza in an urban and a rural community in South Africa, 2017–18 (PHIRST): a population cohort study

Cheryl Cohen et al.

Lancet Global Health (2021)

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Review Medicine, General & Internal

Comparison of Antiviral Agents for Seasonal Influenza Outcomes in Healthy Adults and Children A Systematic Review and Network Meta-analysis

Jen-Wei Liu et al.

Summary: This study compared the efficacy and safety of neuraminidase inhibitors and the endonuclease inhibitor for the treatment of seasonal influenza among healthy adults and children. The results showed that zanamivir was associated with the shortest time to alleviation of influenza symptoms, while baloxavir was associated with reduced rate of influenza-related complications.

JAMA NETWORK OPEN (2021)

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Article Public, Environmental & Occupational Health

Surveillance of Vaccination Coverage Among Adult Populations - United States, 2018

Peng-Jun Lu et al.

Summary: The translation highlights that many adults are at risk for illness and death from vaccine-preventable diseases. Despite the longstanding recommendations for vaccination, the coverage among U.S. adults remains low. The data indicate that substantial improvement in adult vaccination uptake is needed to reduce the burden of vaccine-preventable diseases.

MMWR SURVEILLANCE SUMMARIES (2021)

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Article Infectious Diseases

Home collection of nasal swabs for detection of influenza in the Household Influenza Vaccine Evaluation Study

Ryan E. Malosh et al.

Summary: Research shows that in community settings, home-collection of nasal swab specimens for identification of influenza virus infections is both feasible and reliable.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2021)

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Article Immunology

Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS)

Rueshandra Roosenhoff et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis

Louise E. Lansbury et al.

CRITICAL CARE MEDICINE (2020)

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Article Microbiology

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

Masaki Imai et al.

NATURE MICROBIOLOGY (2020)

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Article Infectious Diseases

Influenza increases invasive meningococcal disease risk in temperate countries

A. Salomon et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

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Review Public, Environmental & Occupational Health

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Huiying Chua et al.

EPIDEMIOLOGY (2020)

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Review Pharmacology & Pharmacy

Favipiravir, an anti-influenza drug against life-threatening RNA virus infections

Kimiyasu Shiraki et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Review Virology

Epidemiology and Clinical Characteristics of Influenza C Virus

Bethany K. Sederdahl et al.

VIRUSES-BASEL (2020)

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Review Public, Environmental & Occupational Health

Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

Xin Wang et al.

LANCET GLOBAL HEALTH (2020)

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Article Immunology

Presence of Influenza Virus on Touch Surfaces in Kindergartens and Primary Schools

Min Whui Fong et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Public, Environmental & Occupational Health

Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study

Benjamin J. Cowling et al.

LANCET PUBLIC HEALTH (2020)

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Review Critical Care Medicine

Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion

Paul E. Verweij et al.

INTENSIVE CARE MEDICINE (2020)

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Article Critical Care Medicine

Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials

Saad B Omer et al.

Lancet Respiratory Medicine (2020)

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Article Medicine, General & Internal

Acute Cardiovascular Events Associated With Influenza in Hospitalized Adults A Cross-sectional Study

Eric J. Chow et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Article Infectious Diseases

Early treatment with baloxavir marboxil in high-risk adolescent and adult outpatients with uncomplicated influenza (CAPSTONE-2): a randomised, placebo-controlled, phase 3 trial

Michael G Ison et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Multidisciplinary Sciences

Influenza A virus is transmissible via aerosolized fomites

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Article Virology

Influenza D virus

Runxia Liu et al.

CURRENT OPINION IN VIROLOGY (2020)

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Article Medicine, General & Internal

Evaluation of a city-wide school-located influenza vaccination program in Oakland, California, with respect to vaccination coverage, school absences, and laboratory-confirmed influenza: A matched cohort study

Jade Benjamin-Chung et al.

PLOS MEDICINE (2020)

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Article Public, Environmental & Occupational Health

Decreased Influenza Activity During the COVID-19 Pandemic — United States, Australia, Chile, and South Africa, 2020

Sonja J. Olsen et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

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Host ANP32A mediates the assembly of the influenza virus replicase

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NATURE (2020)

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Development and Implementation of an Influenza Point-Of-Care Testing Service in a Chain Community Pharmacy Setting

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PHARMACY (2020)

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Article Respiratory System

The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study Rationale and Design

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ANNALS OF THE AMERICAN THORACIC SOCIETY (2020)

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Review Immunology

Nonpharmaceutical Measures for Pandemic Influenza in Nonhealthcare Settings-International Travel-Related Measures

Sukhyun Ryu et al.

EMERGING INFECTIOUS DISEASES (2020)

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Review Immunology

Nonpharmaceutical Measures for Pandemic Influenza in Nonhealthcare Settings-Personal Protective and Environmental Measures

Jingyi Xiao et al.

EMERGING INFECTIOUS DISEASES (2020)

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Article Immunology

Influenza Vaccines: Good, but We Can Do Better

Catharine I. Paules et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

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Article Infectious Diseases

Pregnancy as a risk factor for severe influenza infection: an individual participant data meta-analysis

Dominik Mertz et al.

BMC INFECTIOUS DISEASES (2019)

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Article Medicine, General & Internal

N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel A Randomized Clinical Trial

Lewis J. Radonovich et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

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Article Immunology

Convening on the influenza human viral challenge model for universal influenza vaccines, Part 2: Methodologic considerations

Bruce L. Innis et al.

VACCINE (2019)

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Article Immunology

Meeting report: Convening on the influenza human viral challenge model for universal influenza vaccines, Part 1: Value; challenge virus selection; regulatory, industry and ethical considerations; increasing standardization, access and capacity

Bruce L. Innis et al.

VACCINE (2019)

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Article Immunology

The partnership for influenza vaccine introduction (PIVI): Supporting influenza vaccine program development in low and middle-income countries through public-private partnerships

Joseph S. Bresee et al.

VACCINE (2019)

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Article Microbiology

Environmental Persistence of Influenza Viruses Is Dependent upon Virus Type and Host Origin

Karen A. Kormuth et al.

MSPHERE (2019)

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Article Immunology

Early Oseltamivir After Hospital Admission Is Associated With Shortened Hospitalization: A 5-Year Analysis of Oseltamivir Timing and Clinical Outcomes

Jeremy Katzen et al.

CLINICAL INFECTIOUS DISEASES (2019)

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Article Immunology

Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza

Timothy M. Uyeki et al.

CLINICAL INFECTIOUS DISEASES (2019)

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Review Microbiology

Host and viral determinants of influenza A virus species specificity

Jason S. Long et al.

NATURE REVIEWS MICROBIOLOGY (2019)

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Review Biotechnology & Applied Microbiology

The safety of inactivated influenza vaccines in pregnancy for birth outcomes: a systematic review

Michelle L. Giles et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2019)

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Article Immunology

Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019

Emi Takashita et al.

EMERGING INFECTIOUS DISEASES (2019)

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Article Immunology

A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases

Emily J. Erbelding et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

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Article Immunology

Influenza Virus Infectivity Is Retained in Aerosols and Droplets Independent of Relative Humidity

Karen A. Kormuth et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

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Article Medicine, General & Internal

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

A. Danielle Iuliano et al.

LANCET (2018)

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Article Infectious Diseases

The eyes have it: influenza virus infection beyond the respiratory tract

Jessica A. Belser et al.

LANCET INFECTIOUS DISEASES (2018)

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Article Immunology

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Jake Dunning et al.

NATURE IMMUNOLOGY (2018)

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Article Medicine, General & Internal

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection

Jeffrey C. Kwong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Multidisciplinary Sciences

Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community

Jing Yan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Immunology

Economic burden of seasonal influenza in the United States

Wayan C. W. S. Putri et al.

VACCINE (2018)

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Article Multidisciplinary Sciences

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil

Shinya Omoto et al.

SCIENTIFIC REPORTS (2018)

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Editorial Material Medicine, General & Internal

Gaps in the Clinical Management of Influenza A Century Since the 1918 Pandemic

Timothy M. Uyeki et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Article Medicine, General & Internal

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents

Frederick G. Hayden et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Immunology

Influenza vaccine effectiveness in preventing influenza-associated intensive care admissions and attenuating severe disease among adults in New Zealand 2012-2015

Mark G. Thompson et al.

VACCINE (2018)

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Article Infectious Diseases

The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09

Chandini Raina MacIntyre et al.

BMC INFECTIOUS DISEASES (2018)

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Review Immunology

Efficacy and Safety of Oseltamivir in Children: Systematic Review and Individual Patient Data Meta-analysis of Randomized Controlled Trials

Ryan E. Malosh et al.

CLINICAL INFECTIOUS DISEASES (2018)

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Article Immunology

Seasonal Incidence of Symptomatic Influenza in the United States

Jerome I. Tokars et al.

CLINICAL INFECTIOUS DISEASES (2018)

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Article Immunology

Detection of Respiratory Viruses in Deceased Persons, Spain, 2017

Ana Navascues et al.

EMERGING INFECTIOUS DISEASES (2018)

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Review Infectious Diseases

The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection

Subhashini A. Sellers et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2017)

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Review Infectious Diseases

Effectiveness of influenza vaccines in preventing severe influenza illness among adults: A systematic review and meta-analysis of test-negative design case-control studies

Marc Rondy et al.

JOURNAL OF INFECTION (2017)

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Review Medicine, General & Internal

Influenza

Catharine Paules et al.

LANCET (2017)

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Article Multidisciplinary Sciences

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

Seth J. Zost et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Review Medicine, General & Internal

Diagnostic Accuracy of Novel and Traditional Rapid Tests for Influenza Infection Compared With Reverse Transcriptase Polymerase Chain Reaction A Systematic Review and Meta-analysis

Joanna Merckx et al.

ANNALS OF INTERNAL MEDICINE (2017)

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Article Immunology

Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis

Sudhir Venkatesan et al.

CLINICAL INFECTIOUS DISEASES (2017)

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Article Critical Care Medicine

Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection An Open-label Randomized, Controlled, Phase IIb/III Trial

Ivan F. N. Hung et al.

CHEST (2017)

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Review Immunology

Aberrant coagulation causes a hyper-inflammatory response in severe influenza pneumonia

Yan Yang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2016)

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Review Infectious Diseases

Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies

D. Mertz et al.

EUROSURVEILLANCE (2016)

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Review Infectious Diseases

The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis

Eili Y. Klein et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2016)

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Review Biochemistry & Molecular Biology

Household Transmission of Influenza Virus

Tim K. Tsang et al.

TRENDS IN MICROBIOLOGY (2016)

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Article Immunology

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

Zhongshan Cheng et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

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Article Medicine, General & Internal

Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials

Joanna Dobson et al.

LANCET (2015)

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Review Virology

Prevalence of gastrointestinal symptoms in patients with influenza, clinical significance, and pathophysiology of human influenza viruses in faecal samples: what do we know?

Laetitia Minodier et al.

VIROLOGY JOURNAL (2015)

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Review Public, Environmental & Occupational Health

Serial Intervals of Respiratory Infectious Diseases: A Systematic Review and Analysis

Margaretha Annelie Vink et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2014)

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Article Infectious Diseases

Estimates of the reproduction number for seasonal, pandemic, and zoonotic influenza: a systematic review of the literature

Matthew Biggerstaff et al.

BMC INFECTIOUS DISEASES (2014)

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Article Critical Care Medicine

Surfactant Protein B Gene Polymorphism Is Associated With Severe Influenza

Kelvin K. W. To et al.

CHEST (2014)

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Article Immunology

Influenza Vaccine Effectiveness in the 2011-2012 Season: Protection Against Each Circulating Virus and the Effect of Prior Vaccination on Estimates

Suzanne E. Ohmit et al.

CLINICAL INFECTIOUS DISEASES (2014)

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Article Immunology

The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts

Matthew J. Memoli et al.

CLINICAL INFECTIOUS DISEASES (2014)

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Review Infectious Diseases

Systematic review of influenza A(H1N1)pdm09 virus shedding: duration is affected by severity, but not age

James E. Fielding et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2014)

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Article Critical Care Medicine

Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data

Stella G. Muthuri et al.

LANCET RESPIRATORY MEDICINE (2014)

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Article Critical Care Medicine

Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study

Andrew C. Hayward et al.

LANCET RESPIRATORY MEDICINE (2014)

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Article Critical Care Medicine

Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection

Estefania Herrera-Ramos et al.

CRITICAL CARE (2014)

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Article Infectious Diseases

Influenza encephalopathy and related neuropsychiatric syndromes

Masashi Mizuguchi

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2013)

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Article Microbiology

New World Bats Harbor Diverse Influenza A Viruses

Suxiang Tong et al.

PLOS PATHOGENS (2013)

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Article Immunology

Seasonality, Timing, and Climate Drivers of Influenza Activity Worldwide

Eduardo Azziz Baumgartner et al.

JOURNAL OF INFECTIOUS DISEASES (2012)

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Review Infectious Diseases

Antiviral resistance during the 2009 influenza A H1N1 pandemic: public health, laboratory, and clinical perspectives

Aeron C. Hurt et al.

LANCET INFECTIOUS DISEASES (2012)

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Article Multidisciplinary Sciences

IFITM3 restricts the morbidity and mortality associated with influenza

Aaron R. Everitt et al.

NATURE (2012)

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Article Multidisciplinary Sciences

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

Gui-Mei Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Letter Medicine, General & Internal

Respiratory Failure Caused by 2009 Novel Influenza A/H1N1 in a Hematopoietic Stem-Cell Transplant Recipient: Detection of Extrapulmonary H1N1 RNA and Use of Intravenous Peramivir

Angela P. Campbell et al.

ANNALS OF INTERNAL MEDICINE (2010)

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Article Immunology

Viral Shedding and Clinical Illness in Naturally Acquired Influenza Virus Infections

Lincoln L. H. Lau et al.

JOURNAL OF INFECTIOUS DISEASES (2010)

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Article Medicine, General & Internal

Severe 2009 H1N1 Influenza in Pregnant and Postpartum Women in California

Janice K. Louie et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Article Immunology

Transmission of Influenza Virus via Aerosols and Fomites in the Guinea Pig Model

Samira Mubareka et al.

JOURNAL OF INFECTIOUS DISEASES (2009)

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Review Infectious Diseases

Incubation periods of acute respiratory viral infections: a systematic review

Justin Lessler et al.

LANCET INFECTIOUS DISEASES (2009)

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Review Public, Environmental & Occupational Health

Time lines of infection and disease in human influenza: A review of volunteer challenge studies

Fabrice Carrat et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2008)

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Review Hematology

Influenza viremia and the potential for blood-borne transmission

Anna M. Likos et al.

TRANSFUSION (2007)

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Article Medicine, General & Internal

Influenza-associated deaths among children in the United States, 2003-2004

N Bhat et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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