Autologous chondrocyte implantation in the knee is effective in skeletally immature patients: a systematic review

Article Orthopedics

High Rates of Damage to the Medial Patellofemoral Ligament, Lateral Trochlea, and Patellar Crest After Acute Patellar Dislocation: Magnetic Resonance Imaging Analysis

Filippo Migliorini et al.

Summary: This study analyzed 175 patients who underwent MRI after acute primary patellar dislocation and found that 92% of patients experienced MPFL damage, with chondral damage at the patellar crest being the most common.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2022)

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Review Medicine, General & Internal

Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review

Filippo Migliorini et al.

Summary: Chondral defects of the knee are common and challenging to treat. Both AMIC and mACI have been used for managing these defects, but their equivalent outcomes at midterm follow-up are debated. Further studies are needed to investigate whether AMIC provides superior outcomes compared to mACI.

BRITISH MEDICAL BULLETIN (2022)

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Article Health Care Sciences & Services

Short-term radiological results after spheroid-based autologous chondrocyte implantation in the knee are independent of defect localisation

David Grevenstein et al.

Summary: The study found that short-term radiological outcomes after spheroid-based ACI in the knee are not affected by defect localization, showing good results regardless of the area of the defect.

TECHNOLOGY AND HEALTH CARE (2022)

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Article Orthopedics

Fibrin glue does not assist migration and proliferation of chondrocytes in collagenic membranes: an in vitro study

Filippo Migliorini et al.

Summary: This study evaluated the impact of fibrin glue on chondrocyte loaded collagenic membrane and found that fibrin glue leads to decreased migration and proliferation of chondrocytes.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2022)

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Article Orthopedics

Knee osteochondritis dissecans-treatment technical aspects

Mats Brittberg

Summary: This paper aims to summarize treatment alternatives for different stages of knee osteochondritis dissecans (OCD) based on patient age and the stability of the affected osteochondral area. Good clinical results can be expected when the patients are still growing, the osteochondritis is small, and the stability of the condition is confirmed by MRI. Unstable OCD lesions typically require operative treatment with fixation methods, and if refixation is not possible, various local chondral and osteochondral repairs are available. The final treatment choice depends on the viability and form of the fragments.

JOURNAL OF ORTHOPAEDICS (2022)

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Review Orthopedics

Arthroscopy versus mini-arthrotomy approach for matrix-induced autologous chondrocyte implantation in the knee: a systematic review

Filippo Migliorini et al.

Summary: In midterm follow-up, arthroscopy and mini-arthrotomy approaches for matrix-induced autologous chondrocyte implantation in knee show similar outcomes, including duration of symptoms, age, body mass index, gender, defect size, Tegner Score, Lysholm Score, International Knee Documentation Committee (IKDC) Score, as well as failure rate and revision rate.

JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY (2021)

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Review Orthopedics

Arthroscopic Management of Femoroacetabular Impingement in Adolescents: A Systematic Review

Filippo Migliorini et al.

Summary: Arthroscopic surgery for FAI in adolescents shows excellent outcomes, with a high rate of return to sport and low rates of complications (1%) and revision surgery (5%).

AMERICAN JOURNAL OF SPORTS MEDICINE (2021)

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Review Medicine, General & Internal

Matrix-induced autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis for chondral defects of the talus: a systematic review

Filippo Migliorini et al.

Summary: The treatment of chondral defects of the talus is challenging, with membrane-induced autologous chondrocyte implantation (mACI) and autologous matrix-induced chondrogenesis (AMIC) proposed as methods. There is controversy over whether AMIC provides better outcomes compared to mACI for chondral regeneration, with further research needed to clarify the best treatment method.

BRITISH MEDICAL BULLETIN (2021)

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Review Medicine, General & Internal

Membrane scaffolds for matrix-induced autologous chondrocyte implantation in the knee: a systematic review

Filippo Migliorini et al.

Summary: Chondral defects of the knee are common and challenging to manage. While membrane-induced autologous chondrocyte implantation (mACI) has been widely used, the effectiveness of hyaluronic acid membrane compared to collagenic membrane at midterm follow-up is controversial, requiring further research for validation.

BRITISH MEDICAL BULLETIN (2021)

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Review Orthopedics

Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis

Filippo Migliorini et al.

Summary: AMIC procedure for focal chondral defects of the knee performed better overall at approximately 3 years' follow-up, showing higher Lysholm score, Tegner score, lower rate of failures, and revisions.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Article Orthopedics

Distinguishing between congenital phenomena and traumatic experiences: Osteochondrosis versus osteochondritis

Bruce M. Rothschild et al.

Summary: This study utilized surface microscopy to distinguish between osteochondrosis and osteochondritis, revealing differences in the morphology and vascular nature of these two conditions on the articular surface.

JOURNAL OF ORTHOPAEDICS (2021)

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Article Rehabilitation

Responsiveness of a Persian version of Knee Injury and Osteoarthritis Outcome Score and Tegner activity scale in athletes with anterior cruciate ligament reconstruction following physiotherapy treatment

Neda Mostafaee et al.

PHYSIOTHERAPY THEORY AND PRACTICE (2020)

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Review Cell & Tissue Engineering

Autologous Chondrocyte Implantation and Mesenchymal Stem Cells for the Treatments of Chondral Defects of the Knee- A Systematic Review

Filippo Migliorini et al.

CURRENT STEM CELL RESEARCH & THERAPY (2020)

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Article Orthopedics

Prospective Long-term Follow-up of Autologous Chondrocyte Implantation With Periosteum Versus Matrix-Associated Autologous Chondrocyte Implantation: A Randomized Clinical Trial

Alexander Barie et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2020)

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Article Orthopedics

Comparative Effectiveness of Cartilage Repair With Respect to the Minimal Clinically Important Difference

Kristofer J. Jones et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2019)

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Article Medicine, General & Internal

Autologous Matrix-Induced Chondrogenesis (AMIC) and AMIC Enhanced by Autologous Concentrated Bone Marrow Aspirate (BMAC) Allow for Stable Clinical and Functional Improvements at up to 9 Years Follow-Up: Results from a Randomized Controlled Study

Laura de Girolamo et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Biotechnology & Applied Microbiology

Pediatric Mesenchymal Stem Cells Exhibit Immunomodulatory Properties Toward Allogeneic T and B Cells Under Inflammatory Conditions

Virginia Palomares Cabeza et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Article Orthopedics

Recurrence of Patellar Instability in Adolescents Undergoing Surgery for Osteochondral Defects Without Concomitant Ligament Reconstruction

Jason M. Pedowitz et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2019)

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Article Orthopedics

Matrix-Associated Autologous Chondrocyte Implantation Is an Effective Treatment at Midterm Follow-up in Adolescents and Young Adults

Arnd Hoburg et al.

ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE (2019)

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Article Orthopedics

Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture Five-Year Follow-up of a Prospective Randomized Trial

Mats Brittberg et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2018)

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Article Orthopedics

Treatment of large deep osteochondritis lesions of the knee by autologous matrix-induced chondrogenesis (AMIC): Preliminary results in 13 patients

Pierre Bertho et al.

ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH (2018)

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Article Environmental Sciences

Evaluation of the risk of bias in non-randomized studies of interventions (ROBINS- I) and the 'target experiment' concept in studies of exposures: Rationale and preliminary instrument development

Rebecca L. Morgan et al.

ENVIRONMENT INTERNATIONAL (2018)

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Article Orthopedics

Mid and long term outcomes after fixation of osteochondritis dissecans

Mitsuaki Kubota et al.

JOURNAL OF ORTHOPAEDICS (2018)

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Article Orthopedics

Autologous Chondrocyte Implantation Improves Knee-Specific Functional Outcomes and Health-Related Quality of Life in Adolescent Patients

Gregory L. Cvetanovich et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2017)

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Article Orthopedics

Matrix based autologous chondrocyte implantation in children and adolescents: a match paired analysis in a follow-up over three years post-operation

Thomas Richard Niethammer et al.

INTERNATIONAL ORTHOPAEDICS (2017)

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Article Orthopedics

Long-term Outcomes of Autologous Chondrocyte Implantation in Adolescent Patients

Takahiro Ogura et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2017)

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Review Sport Sciences

Knee Articular Cartilage Repair and Restoration Techniques: A Review of the Literature

Dustin L. Richter et al.

SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH (2016)

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Article Orthopedics

Validity and Comprehensibility of Physical Activity Scales for Children With Sport Injuries

Maura D. Iversen et al.

JOURNAL OF PEDIATRIC ORTHOPAEDICS (2016)

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Article Orthopedics

Matrix-induced autologous chondrocyte implantation (MACI) in the knee: clinical outcomes and challenges

Erhan Basad et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2015)

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Article Sport Sciences

Osteochondritis Dissecans of the Knee Pathoanatomy, Epidemiology, and Diagnosis

Nathan L. Grimm et al.

CLINICS IN SPORTS MEDICINE (2014)

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Article Orthopedics

Cell-based Therapy Improves Function in Adolescents and Young Adults With Patellar Osteochondritis Dissecans

Bryon J. X. Teo et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2013)

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Review Pharmacology & Pharmacy

Is autologous chondrocyte implantation (ACI) an adequate treatment option for repair of cartilage defects in paediatric patients?

Marietta Kaszkin-Bettag

DRUG DISCOVERY TODAY (2013)

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Review Cell & Tissue Engineering

New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics

Nicola Giuliani et al.

STEM CELLS INTERNATIONAL (2013)

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Article Orthopedics

Development of the Knee Injury and Osteoarthritis Outcome Score for Children (KOOS-Child) Comprehensibility and content validity

Maria Ortqvist et al.

ACTA ORTHOPAEDICA (2012)

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Article Orthopedics

Reliability, Validity, and Responsiveness of a Modified International Knee Documentation Committee Subjective Knee Form (Pedi-IKDC) in Children With Knee Disorders

Mininder S. Kocher et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2011)

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Article Orthopedics

Autologous Chondrocyte Implantation in the Adolescent Knee

Simon Macmull et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2011)

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Article Rheumatology

Measures of Knee Function International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL), Lysholm Knee Scoring Scale, Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Activity Rating Scale (ARS), and Tegner Activity Score (TAS)

Natalie J. Collins et al.

ARTHRITIS CARE & RESEARCH (2011)

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Article Orthopedics

Guidelines for the Design and Conduct of Clinical Studies in Knee Articular Cartilage Repair: International Cartilage Repair Society Recommendations Based on Current Scientific Evidence and Standards of Clinical Care

Kai Mithoefer et al.

CARTILAGE (2011)

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Article Orthopedics

Autologous Chondrocyte Implantation Using the Original Periosteum-Cover Technique Versus Matrix-Associated Autologous Chondrocyte Implantation A Randomized Clinical Trial

Felix Zeifang et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2010)

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Article Orthopedics

Autologous Bone Marrow-Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation An Observational Cohort Study

Hossein Nejadnik et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2010)

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Article Orthopedics

The Reliability, Validity, and Responsiveness of the Lysholm Score and Tegner Activity Scale for Anterior Cruciate Ligament Injuries of the Knee

Karen K. Briggs et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2009)

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Article Medicine, General & Internal

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

David Moher et al.

BMJ-BRITISH MEDICAL JOURNAL (2009)

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Article Biophysics

Potential role of mesenchymal stromal cells in pediatric hematopoietic SCT

L. M. Ball et al.

BONE MARROW TRANSPLANTATION (2008)

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Article Orthopedics

Surgical suturing of articular cartilage induces osteoarthritis-like changes

E. B. Hunziker et al.

OSTEOARTHRITIS AND CARTILAGE (2008)

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Article Orthopedics

Classification of graft hypertrophy after autologous chondrocyte implantation of full-thickness chondral defects in the knee

P. C. Kreuz et al.

OSTEOARTHRITIS AND CARTILAGE (2007)

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Article Orthopedics

Articular cartilage repair in the adolescent athlete: Is autologous chondrocyte implantation the answer?

Lyle Micheli et al.

CLINICAL JOURNAL OF SPORT MEDICINE (2006)

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Article Surgery

Matrix-coupled microfracture. A new concept for cartilage defect repair

P. Behrens

ARTHROSKOPIE (2005)

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Article Orthopedics

Functional outcome of knee articular cartilage repair in adolescent athletes

K Mithöfer et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2005)

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Review Orthopedics

Cartilage restoration, part 1 - Basic science, historical perspective, patient evaluation, and treatment options

JW Alford et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2005)

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Article Orthopedics

Development and validation of the International Knee Documentation Committee Subjective Knee Form

JJ Irrgang et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2001)

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Autologous chondrocyte implantation in the knee is effective in skeletally immature patients: a systematic review

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