Impact of Portal Hypertension on Adverse Events after Splenic Arterial Aneurysm Embolization

Purpose: To evaluate the outcomes of splenic artery aneurysm (SAA) embolization and compare adverse event (AE) rates after embolization in patients with and without portal hypertension (PHTN). Materials and Methods: A retrospective review of all patients who underwent embolization of SAAs at 2 institutions was performed (34 patients from institution 1 and 7 patients from institution 2). Baseline demographic characteristics, preprocedural imaging, procedural techniques, and postprocedural outcomes were evaluated. Thirty-day postprocedural severe and life-threatening AEs were evaluated using the Society of Interventional Radiology guidelines. Thirty-day mortality and readmission rates were also evaluated. t test,.2 test, and/or Fisher exact test were used for the statistical analysis. Results: There was no statistically significant difference between patients with and without PHTN in the location, number, and size of SAA(s). All procedures were technically successful. There were 13 (32%) patients with and 28 (68%) patients without PHTN. The 30-day mortality rate (31% vs 0%; P =.007), readmission rates (61% vs 7%; P <.001), and severe/life-threatening AE rates (69% vs 0%; P <.001) were significantly higher in patients with PHTN than in those without PHTN. Conclusions: There was a significantly higher mortality and severe/life-threatening AE rate in patients with PHTN than in those without PHTN. SAAs in patients with PHTN need to be managed very cautiously, given the risk of severe/lifethreatening AEs after embolization.

Automated summary

This study evaluated the outcomes of splenic artery aneurysm embolization and compared the rates of adverse events in patients with and without portal hypertension. The results showed that patients with portal hypertension had significantly higher mortality and severe/life-threatening adverse event rates after embolization.